Dermatology Unit, A. Murri Hospital, Jesi, Italy.
Clin Exp Dermatol. 2009 Dec;34(8):e898-900. doi: 10.1111/j.1365-2230.2009.03670.x.
Atypical fibroxanthoma (AFX) is an uncommon, low-grade, malignant, spindle-cell tumour of fibrohistiocytic histogenesis, which can mimic other malignant skin tumours, such as basal and squamous cell carcinoma (CC), melanoma, and Merkel cell carcinoma (MCC). Three cases of AFX were examined by dermatoscopy, which revealed white areas and an atypical polymorphous vascular pattern characterized by the concurrence of different structures: linear, dotted, hairpin, arborescent and highly tortuous vessels, irregularly distributed over the surface. Seborrhoeic elements and photoageing may be accompanying features depending on the anatomical location of the AFX. AFX may be added to the list of slightly pigmented, reddish, malignant cutaneous tumours, such as SCC, MCC, amelanotic/hypomelanotic melanoma and eccrine porocarcinoma, which display prominent and chaotic dermatoscopic neoangiogenetic features in more advanced stages of proliferation.
非典型纤维黄色瘤(AFX)是一种罕见的、低度恶性、梭形细胞来源的间叶性肿瘤,其组织发生学类似于其他恶性皮肤肿瘤,如基底细胞癌和鳞状细胞癌(CC)、黑色素瘤和 Merkel 细胞癌(MCC)。我们对 3 例 AFX 进行了皮肤镜检查,结果显示白色区域和非典型多形性血管模式,其特征是不同结构的共存:线性、点状、发夹状、树枝状和高度迂曲的血管,不规则分布在表面。皮脂元素和光老化可能是伴随的特征,这取决于 AFX 的解剖位置。AFX 可能被添加到稍微色素沉着、红色、恶性皮肤肿瘤的列表中,如 SCC、MCC、无黑色素/低黑色素黑色素瘤和小汗腺汗孔癌,这些肿瘤在增殖的更晚期表现出明显和混乱的皮肤镜新生血管特征。