Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark.
J Natl Cancer Inst. 2010 Feb 3;102(3):202-6. doi: 10.1093/jnci/djp459. Epub 2010 Jan 7.
Elevated plasma levels of C-reactive protein (CRP), a marker of inflammation, are associated with an increased risk of cancer, but it is unclear whether this association is causal. We examined whether four common single-nucleotide polymorphisms (SNPs) in the CRP gene that are associated with altered plasma CRP levels are causally associated with an increased risk of cancer. The study population included participants in a prospective study (n = 10 215) and a cross-sectional study (n = 36 403) of the adult general population in Denmark, all of whom were genotyped for the CRP SNPs. The association between plasma CRP levels measured by a high-sensitivity turbidimetry assay and the risk of cancer was examined for 8224 participants in the prospective study. The hazard ratio of cancer for a doubling of the plasma CRP level was 1.09 (95% confidence interval [CI] = 1.03 to 1.14). The nine most common genotype combinations of the four CRP SNPs were associated with up to a 72% increase (95% CI = 58% to 87%) in CRP levels but not with an increased risk of cancer. The estimated causal odds ratio for cancer associated with a genetically induced doubling in CRP level was 0.94 (95% CI = 0.81 to 1.08). This finding suggests that elevated CRP levels do not cause cancer.
C 反应蛋白（CRP）是炎症的标志物，其血浆水平升高与癌症风险增加相关，但尚不清楚这种关联是否具有因果关系。我们研究了 CRP 基因中四个常见的单核苷酸多态性（SNP）是否与 CRP 血浆水平的改变有关，以及这些 SNP 是否与癌症风险增加有关。研究人群包括丹麦前瞻性研究（n = 10215）和横断面研究（n = 36403）的成年普通人群中的参与者，所有参与者均进行了 CRP SNP 基因分型。在前瞻性研究中，对 8224 名参与者进行了通过高敏比浊法测定的 CRP 血浆水平与癌症风险之间的关联研究。CRP 血浆水平翻倍时癌症的风险比为 1.09（95%置信区间[CI] = 1.03 至 1.14）。四个 CRP SNP 的九种最常见的基因型组合与 CRP 水平升高最高达 72%（95%CI = 58%至 87%）相关，但与癌症风险增加无关。与 CRP 水平遗传诱导翻倍相关的癌症的估计因果比值为 0.94（95%CI = 0.81 至 1.08）。这一发现表明 CRP 水平升高不会导致癌症。
