DNA修复蛋白在端粒维持中的作用。

Roles of DNA repair proteins in telomere maintenance.

作者信息

Ueno Masaru

机构信息

Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, higashi-Hiroshima, Japan.

出版信息

Biosci Biotechnol Biochem. 2010;74(1):1-6. doi: 10.1271/bbb.90682. Epub 2010 Jan 7.

DOI:10.1271/bbb.90682

PMID:20057153

Abstract

Telomeres are protected and maintained by telomere-specific proteins. In addition, proteins involved in DNA repair, such as Mre11-Rad50-Nbs1 complex, RPA, and RecQ helicase, are also involved in telomere maintenance. In this review, the roles of these proteins in telomere maintenance and their functional relationships to the telomere-specific proteins will be discussed.

摘要

端粒由端粒特异性蛋白保护和维持。此外，参与DNA修复的蛋白，如Mre11-Rad50-Nbs1复合物、RPA和RecQ解旋酶，也参与端粒的维持。在这篇综述中，将讨论这些蛋白在端粒维持中的作用以及它们与端粒特异性蛋白的功能关系。