Ermakova O N, Ermakov A M, Tiras Kh P, Lednev V V
Ontogenez. 2009 Nov-Dec;40(6):449-55.
The effect of retinoic acid on regeneration of two species of asexual planarian races, Girardia tigrina and Schmidtea mediterranea, was studied. It was established that retinoic acids at physiological concentrations (10(-7)-10(-10) M) inhibit the regeneration of the head part of planarians but have no effect on tail blastema growth. It is shown that regeneration of the head part is inhibited as a result of arrest of the cell cycle of neoblasts, proliferating stem cells, during the transition from the G1/G0 to the S phase. Thus, the morphogenetic role of retinoic acids in planarians, primitive bilaterally symmetrical animals, has been demonstrated.
研究了视黄酸对两种无性涡虫种族，即虎纹涡虫（Girardia tigrina）和地中海涡虫（Schmidtea mediterranea）再生的影响。结果表明，生理浓度（10⁻⁷ - 10⁻¹⁰ M）的视黄酸会抑制涡虫头部的再生，但对尾部芽基生长没有影响。研究表明，头部再生受到抑制是由于新生细胞（增殖干细胞）在从G1/G0期向S期转变过程中细胞周期停滞所致。因此，视黄酸在涡虫（原始两侧对称动物）中的形态发生作用得以证实。
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