手性钙配合物催化的丙二酸酯与亚胺的不对称曼尼希反应。
Asymmetric mannich reaction of malonates with imines catalyzed by a chiral calcium complex.
机构信息
Department of Chemistry, School of Science and Graduate School of Pharmaceutical Sciences, The University of Tokyo, The HFRE Division, ERATO, Japan Science and Technology Agency (JST), Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
出版信息
J Org Chem. 2010 Feb 5;75(3):963-5. doi: 10.1021/jo902383b.
PMID:20058931
Abstract
A chiral calcium complex was found to be effective for the Mannich reactions of malonates with N-Boc imines. The desired adducts were obtained in excellent yields (up to 95%) with moderate to good enantioselectivities (up to 77% ee).
摘要
手性钙配合物被发现可有效用于丙二酸盐与 N-Boc 亚胺的曼尼希反应。以中等到良好的对映选择性（高达 77%ee）获得了所需的加合物，产率非常好（高达 95%）。
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