BCG 疤痕阅读在 HIV 感染儿童中的敏感性和特异性。

Sensitivity and specificity of BCG scar reading among HIV-infected children.

机构信息

Departamento de Pediatria, Universidade Agostinho Neto, Av. Amilcar Cabral, s/n, Maianga, Luanda, Angola.

出版信息

Vaccine. 2010 Feb 25;28(9):2067-9. doi: 10.1016/j.vaccine.2009.12.034. Epub 2010 Jan 6.

DOI:10.1016/j.vaccine.2009.12.034

PMID:20060085

Abstract

BCG scar has been used as an indicator of vaccination with BCG in the past, but the validity of scar among HIV-positive children is still unknown. The validity of BCG scar reading among such children was estimated, using three different gold standards. The sensitivity ranged from 81.3% (95%-CI: 78.0-84.2) to 91.6% (95%-CI: 88.4-94.0), when the gold standards were, respectively, information from the adult responsible for the child and the vaccination card. The specificity ranged from 90.5% (95% CI: 81.6-95.5) to 94.1% (95% CI: 87.7-97.4), when the gold standards were, respectively, the vaccination card and information from the adult responsible for the child. Reading of BCG scar was shown to be a good indicator for vaccination in the past, among HIV-infected children.

摘要

BCG 疤痕过去曾被用作卡介苗接种的指标，但 HIV 阳性儿童的疤痕有效性仍不清楚。使用三种不同的金标准评估了此类儿童的 BCG 疤痕读数的有效性。当金标准分别为负责儿童的成人的信息和疫苗接种卡时，灵敏度范围为 81.3%（95%-CI：78.0-84.2）至 91.6%（95%-CI：88.4-94.0）。当金标准分别为疫苗接种卡和负责儿童的成人的信息时，特异性范围为 90.5%（95%CI：81.6-95.5）至 94.1%（95%CI：87.7-97.4）。在过去，BCG 疤痕的读取被证明是 HIV 感染儿童接种疫苗的良好指标。