Department of Pharmacology, Pomeranian Medical University, ul. Powst. Wlkp. 72, 70-111 Szczecin, Poland.
Eur J Obstet Gynecol Reprod Biol. 2010 Mar;149(1):82-5. doi: 10.1016/j.ejogrb.2009.12.010. Epub 2010 Jan 13.
Osteoporosis is a common disorder with a strong genetic component. The genetics of osteoporosis impacts on the prediction, diagnosis, prognosis, and treatment of the disease.
The aim of the present study was to examine associations between cytokine gene polymorphisms (IL-1beta, IL-2, IL-6) and bone mineral density (BMD) values in postmenopausal women. The study included 226 postmenopausal women with a diagnosed BMD T-score lower than -2.5 SD (mean: -3.02+/-.053) and 224 postmenopausal women with a BMD T-score greater than -2.5 SD (mean: -1.33+/-0.51).
Among the women with T-scores below -2.5 SD, the BMD values were significantly lower in the carriers of the IL-6 GG genotype compared with those with the CC and GC genotypes (0.70+/-0.38 vs. 0.73+/-0.25 and 0.74+/-0.23 for the lumbar spine, 0.54+/-0.18 vs. 0.56+/-0.15 and 0.58+/-0.22 for the femoral neck). There were no statistically significant associations between the IL-1beta and IL-2 genotypes and BMD values in the group of women with T-scores below -2.5 SD.
The results of the present study suggest an association of the IL-6 -174 G/C polymorphism with osteoporosis in postmenopausal women.
骨质疏松症是一种常见疾病，具有很强的遗传成分。骨质疏松症的遗传学影响疾病的预测、诊断、预后和治疗。
本研究旨在探讨细胞因子基因多态性（IL-1beta、IL-2、IL-6）与绝经后妇女骨密度（BMD）值之间的关系。该研究包括 226 名绝经后妇女，其 BMD T 评分低于-2.5 SD（平均值：-3.02+/-.053），224 名绝经后妇女 BMD T 评分大于-2.5 SD（平均值：-1.33+/-0.51）。
在 T 评分低于-2.5 SD 的女性中，与 CC 和 GC 基因型相比，IL-6 GG 基因型携带者的 BMD 值明显更低（腰椎为 0.70+/-0.38 比 0.73+/-0.25 和 0.74+/-0.23，股骨颈为 0.54+/-0.18 比 0.56+/-0.15 和 0.58+/-0.22）。在 T 评分低于-2.5 SD 的女性中，IL-1beta 和 IL-2 基因型与 BMD 值之间没有统计学上的显著关联。
本研究结果提示 IL-6 -174 G/C 多态性与绝经后妇女骨质疏松症有关。
