[皮肤转移性黑色素瘤的电化学疗法]
[Electrochemotherapy of melanoma cutaneous metastases].
作者信息
Kis Erika, Szegesdi Ilona, Ocsai Henriette, Gyulai Rolland, Kemény Lajos, Oláh Judit
机构信息
Szegedi Tudományegyetem, Altalános Orvostudományi Kar, Borgyógyászati és Allergológiai Klinika, Szeged.
出版信息
Orv Hetil. 2010 Jan 17;151(3):99-101. doi: 10.1556/OH.2010.28781.
UNLABELLED
Electrochemotherapy is an effective treatment of cutaneous and subcutaneous metastases in patients with malignant melanoma. During the treatment, electric pulses are applied to tumor nodules to deliver non-permeating or poorly permeating chemotherapeutic agents into the cells thereby increasing local cytotoxicity of anticancer drugs.
METHODS
In 7 patients 81 cutaneous and subcutaneous melanoma metastases were treated with electrochemotherapy. All treatments were performed under general anesthesia using intravenous bleomycin injection. Median follow-up was 218 days.
RESULTS
Complete response rate was 25%, partial response rate was 43%. We observed no change in 26%, and progressive disease in 6%.
CONCLUSIONS
Electrochemotherapy is a simple and effective treatment of single or multiple cutaneous and subcutaneous metastases of melanoma, with minimal side effects. Our results confirm the results of recently published studies that the treatment used for palliation has clinical benefit and impact on the quality of life.
未标注
电化学疗法是恶性黑色素瘤患者皮肤及皮下转移灶的一种有效治疗方法。治疗过程中，将电脉冲施加于肿瘤结节，使非渗透性或渗透性差的化疗药物进入细胞，从而增强抗癌药物的局部细胞毒性。
方法
对7例患者的81个皮肤及皮下黑色素瘤转移灶进行了电化学疗法治疗。所有治疗均在全身麻醉下使用静脉注射博来霉素进行。中位随访时间为218天。
结果
完全缓解率为25%，部分缓解率为43%。我们观察到26%无变化，6%为疾病进展。
结论
电化学疗法是一种治疗黑色素瘤单个或多个皮肤及皮下转移灶的简单有效方法，副作用极小。我们的结果证实了最近发表的研究结果，即用于姑息治疗的该疗法具有临床益处并对生活质量有影响。
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