Biolato Marco, Gabrieli Maria Letizia, Parente Antonello, Racco Simona, Costantini Melania, Bonomo Lorenzo, Rapaccini Gian Ludovico, Gasbarrini Giovanni, Grieco Antonio
Department of Internal Medicine, Catholic University of Rome, 8 Largo A Gemelli, 00168 Rome, Italy.
J Med Case Rep. 2009 Dec 2;3:9314. doi: 10.1186/1752-1947-3-9314.
Abdominal angina is usually caused by atherosclerotic disease, and other causes are considered uncommon. This is the first report of a case of abdominal angina secondary to neoplastic vascular stenosis caused by local recurrence of an adenocarcinoma of the papilla of Vater.
An 80-year-old woman of Caucasian origin presented with abdominal pain and diarrhea. She had undergone a pancreaticoduodenectomy for adenocarcinoma of the papilla of Vater four years earlier. Computed tomography revealed a mass surrounding her celiac trunk and superior mesenteric artery. Her abdominal pain responded poorly to analgesic drugs, but disappeared when oral feedings were withheld. A duplex ultrasonography of the patient's splanchnic vessels was consistent with vascular stenosis. Parenteral nutrition was started and the patient remained pain free until her death.
Pain relief is an important therapeutic target in patients with cancer. In this case, abdominal pain was successfully managed only after the ischemic cause had been identified. The conventional analgesic therapy algorithm based on nonsteroidal anti-inflammatory drugs and opioids had been costly and pointless, whereas the simple withdrawal of oral feeding spared the patient of the discomfort of additional invasive procedures and allowed her to spend her remaining days in a completely pain-free state.
腹绞痛通常由动脉粥样硬化疾病引起,其他病因较为罕见。本文首次报道了一例因 Vater 乳头腺癌局部复发导致肿瘤性血管狭窄继发腹绞痛的病例。
一名 80 岁的白种女性出现腹痛和腹泻症状。四年前她因 Vater 乳头腺癌接受了胰十二指肠切除术。计算机断层扫描显示其腹腔干和肠系膜上动脉周围有肿块。她的腹痛对镇痛药反应不佳,但禁食时疼痛消失。对患者内脏血管进行的双功超声检查结果与血管狭窄相符。开始给予肠外营养,患者直至去世都未再感到疼痛。
缓解疼痛是癌症患者的重要治疗目标。在此病例中,仅在确定缺血性病因后,腹痛才得到成功控制。基于非甾体抗炎药和阿片类药物的传统镇痛治疗方案既昂贵又无效,而简单的禁食避免了患者接受额外侵入性操作的不适,并使其在余生中完全处于无痛状态。