Dana-Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA.
Neuron. 2009 Dec 24;64(6):773-6. doi: 10.1016/j.neuron.2009.12.014.
The rapidly adapting (RA) low-threshold mechanoreceptors respond to movement of the skin and vibration and are critical for the perception of texture and shape. In this issue of Neuron, two papers (Bourane et al. and Luo et al.) demonstrate that early-born Ret+ sensory neurons are RA mechanoreceptors, whose peripheral nerve terminals are associated with Meissner corpuscles, longitudinal lanceolate endings, and Pacinian corpuscles. The studies further show that Ret signaling is essential for the development of these mechanoreceptors.
快速适应(RA)低阈值机械感受器对皮肤运动和振动有反应,对感知质地和形状至关重要。在本期《神经元》中,两篇论文(Bourane 等人和 Luo 等人)表明,早期出生的 Ret+感觉神经元是 RA 机械感受器,其周围神经末梢与 Meissner 小体、纵长锥形末端和 Pacinian 小体有关。这些研究进一步表明,Ret 信号对于这些机械感受器的发育是必不可少的。