绝经后终末期膝骨关节炎女性继发性甲状旁腺功能亢进的发病率

Incidence of secondary hyperparathyroidism among postmenopausal women with end-stage knee osteoarthritis.

作者信息

Papavasiliou Kyriakos A, Kenanidis Eustathios I, Potoupnis Michael E, Sarris Ioannis K, Kirkos John M, Kapetanos George A

机构信息

3rd Orthopaedic Department, Medical School of the Aristotle University of Thessaloniki, Greece.

出版信息

J Orthop Surg (Hong Kong). 2009 Dec;17(3):310-2. doi: 10.1177/230949900901700313.

DOI:10.1177/230949900901700313

PMID:20065370

Abstract

PURPOSE

To evaluate the incidence of secondary hyperparathyroidism (SH) among postmenopausal women with end-stage knee osteoarthritis scheduled for total knee replacement (TKR).

METHODS

283 Caucasian postmenopausal women aged 49 to 81 (mean, 70) years with end-stage idiopathic knee osteoarthritis were scheduled to undergo primary TKR. They had been menopausal for 7 to 31 (mean, 19) years. Their preoperative serum levels of intact parathyroid hormone (I-PTH), calcium, phosphorus, creatinine, and the clearance of creatinine were evaluated.

RESULTS

100 patients had abnormally elevated serum I-PTH. The overall incidence of SH was 35%. Serum levels of calcium and phosphorus were elevated in 33 and 12 patients, respectively. The serum level of I-PTH correlated positively with patient age (r=0.158, p=0.008) and serum creatinine level (r=0.138, p=0.021) and negatively with clearance of creatinine (r= -0.169, p=0.004).

CONCLUSION

SH is common among elderly postmenopausal women and may affect bone healing and implant fixation. Preoperative screening/evaluation of the serum PTH level in postmenopausal women scheduled for TKR is recommended.

摘要

目的

评估计划进行全膝关节置换术（TKR）的绝经后晚期膝骨关节炎女性患者继发性甲状旁腺功能亢进（SH）的发生率。

方法

283名年龄在49至81岁（平均70岁）的白种人绝经后晚期特发性膝骨关节炎女性计划接受初次TKR。她们绝经7至31年（平均19年）。评估了她们术前血清完整甲状旁腺激素（I-PTH）、钙、磷、肌酐水平以及肌酐清除率。

结果

100名患者血清I-PTH异常升高。SH的总体发生率为35%。分别有33名和12名患者血清钙和磷水平升高。血清I-PTH水平与患者年龄（r = 0.158，p = 0.008）和血清肌酐水平（r = 0.138，p = 0.021）呈正相关，与肌酐清除率呈负相关（r = -0.169，p = 0.004）。