Skare Thelma Laroka, Ribas Carmen Autralia Paredes Marcondes, Malafaia Osvaldo, Ribas Filho Jurandir Marcondes, Nassif Paulo Afonso Nunes, Nascimento Marcelo Mazza do, Pachnicki Jan Pawel Andrade
Programa de Pós-Graduação em Princípios da Cirurgia do Hospital Universitário Evangélico de Curitiba/Faculdade Evangélica do Paraná, Curitiba, PR - BR.
Rev Col Bras Cir. 2009 Oct;36(5):420-4. doi: 10.1590/s0100-69912009000500010.
To study the prevalence of anticardiolipin antibodies in patients with venous, diabetic and arterial leg ulcers and to verify if platelet count, previous history of venous thrombosis, obstetrical history and the finding of livedo reticularis are markers of this autoantibody positivity.
151 patients with leg ulcer (81 with venous, 50 with diabetic and 20 with arterial ulcers) and 150 controls were included. In both groups search for the presence of IgG and IgM anticardiolipin and platelet count was done. In the leg ulcer group demographic data, obstetrical history, previous history of venous thrombosis as well as presence of livedo reticularis by physical examination were pointed out. Data was grouped in contingency and frequency tables and the tests of Fisher and chi-squared were used for nominal variables and Mann Whitney and Kruskall Wallis for numerical variables. The adopted significance was of 5%.
It was found an anticardiolipin prevalence of 7.2% (n=12) in the leg ulcer group and of 1.3% (n=2) in the control group (p=0.01). Leg ulcer patients with anticardiolipin did not differ from those without it in gender (p=0.98), previous history of venous thrombosis (p=0.69), previous history of abortions (p=0.67) and platelet count (p=0.67). Only two patients had livedo reticularis which precluded any conclusion on this data.
There is an increased prevalence of anticardiolipin antibodies in the general population with leg ulcers. Clinical characteristics of ulcers as well as platelet count do not help in the identification of these patients.
研究静脉性、糖尿病性和动脉性腿部溃疡患者中抗心磷脂抗体的患病率，并验证血小板计数、既往静脉血栓形成史、产科病史以及网状青斑的发现是否为此自身抗体阳性的标志物。
纳入151例腿部溃疡患者（81例静脉性溃疡、50例糖尿病性溃疡和20例动脉性溃疡）和150例对照。两组均检测IgG和IgM抗心磷脂抗体的存在情况并进行血小板计数。在腿部溃疡组中，指出人口统计学数据、产科病史、既往静脉血栓形成史以及体格检查时网状青斑的存在情况。数据整理成列联表和频率表，对于名义变量使用Fisher检验和卡方检验，对于数值变量使用Mann-Whitney检验和Kruskall-Wallis检验。采用的显著性水平为5%。
发现腿部溃疡组抗心磷脂抗体患病率为7.2%（n = 12），对照组为1.3%（n = 2）（p = 0.01）。抗心磷脂抗体阳性的腿部溃疡患者与阴性患者在性别（p = 0.98）、既往静脉血栓形成史（p = 0.69）、既往流产史（p = 0.67）和血小板计数（p = 0.67）方面无差异。仅2例患者有网状青斑，因此无法据此得出任何结论。
腿部溃疡人群中抗心磷脂抗体患病率增加。溃疡的临床特征以及血小板计数无助于识别这些患者。
