口腔黏膜下纤维性变的成瘾因素、人乳头瘤病毒感染与组织病理学的相关性。

Correlation of addictive factors, human papilloma virus infection and histopathology of oral submucous fibrosis.

机构信息

Department of Pathology, Moti Lal Nehru Medical College, Allahabad, India.

出版信息

J Oral Pathol Med. 2010 Jul;39(6):460-4. doi: 10.1111/j.1600-0714.2009.00849.x. Epub 2010 Jan 8.

DOI:10.1111/j.1600-0714.2009.00849.x

PMID:20070487

Abstract

BACKGROUND

Oral submucous fibrosis (OSMF) is a widely prevalent, potentially malignant disorder of the oral cavity in the Indian subcontinent. Areca nut has been incriminated as the main causative factor. However, other factors, including viruses may also play a role in the initiation/development of these lesions. This study was designed to assess the correlation of addictive factors, human papilloma virus infection and histopathology of OSMF.

METHODS

One hundred and thirteen cases of OSMF were studied. Demographic information of each patient, including the patient's age, sex, addiction habits and histopathological grading was obtained. Presence of high-risk human papilloma virus (HR-HPV) DNA was detected using the Hybrid Capture II assay.

RESULTS

Of 105 cases finally included in the study, 33 (31.4%) patients were found to be positive for HR-HPV, while 72 (68.6%) were negative. A total of 52/105 (49.5%) patients chewed areca nut, of whom 18 (34.6%) patients were found to be positive and 34 (63.5%) were negative (P = 0.08). A total of 18/105 (17.1%) patients were addicted to smoking, of whom five (27.7%) were positive (0.69). Only one (11.1%) patient, who was only habituated to alcohol, was positive (1.08). Of the 105 patients 26 (24.7%) chewed as well as smoked tobacco, of whom, nine (34.6%) were positive and 17(65.3%) were negative (P = 0.67). Thus, there was no significant association between the various addiction habits and the presence of HR-HPV. On correlating the various histopathological grades of the disease with HR-HPV positivity a Pearson correlation of 0.053 was obtained (P = 0.588). Thus, again no significant correlation was observed between the different histopathological grades and HR-HPV positivity.

CONCLUSION

In conclusion, it was found that there is neither significant correlation between HR-HPV infection and the various addiction habits nor with the different histopathological grades of the disease. To the best of our knowledge, a study of these different factors has never been attempted before in patients with OSMF.

摘要

背景

口腔黏膜下纤维性变（OSMF）是印度次大陆口腔中一种广泛存在的、潜在恶性的疾病。槟榔被认为是主要的致病因素。然而，其他因素，包括病毒，也可能在这些病变的发生/发展中起作用。本研究旨在评估成瘾因素、人乳头瘤病毒（HPV）感染与 OSMF 的组织病理学之间的相关性。

方法

研究了 113 例 OSMF 患者。获取了每位患者的人口统计学信息，包括患者年龄、性别、成瘾习惯和组织病理学分级。使用杂交捕获 II 法检测高危型人乳头瘤病毒（HR-HPV）DNA 的存在。

结果

在最终纳入研究的 105 例病例中，33 例（31.4%）患者 HR-HPV 检测呈阳性，72 例（68.6%）患者 HR-HPV 检测呈阴性。共有 52/105（49.5%）例患者咀嚼槟榔，其中 18 例（34.6%）患者 HR-HPV 检测呈阳性，34 例（63.5%）患者 HR-HPV 检测呈阴性（P=0.08）。共有 18/105（17.1%）例患者吸烟成瘾，其中 5 例（27.7%）患者 HR-HPV 检测呈阳性（0.69）。仅 1 例（11.1%）仅习惯饮酒的患者 HR-HPV 检测呈阳性（1.08）。在 105 例患者中，26 例（24.7%）同时咀嚼烟草和槟榔，其中 9 例（34.6%）患者 HR-HPV 检测呈阳性，17 例（65.3%）患者 HR-HPV 检测呈阴性（P=0.67）。因此，各种成瘾习惯与 HR-HPV 的存在之间没有显著关联。在将疾病的各种组织病理学分级与 HR-HPV 阳性相关联时，获得了 0.053 的 Pearson 相关系数（P=0.588）。因此，也未观察到不同组织病理学分级与 HR-HPV 阳性之间存在显著相关性。