新型结构机制对 COPII 衣被的深入了解。

New insights into the structural mechanisms of the COPII coat.

机构信息

Institute for Molecular Biophysics, Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA.

出版信息

Traffic. 2010 Mar;11(3):303-10. doi: 10.1111/j.1600-0854.2009.01026.x. Epub 2009 Dec 7.

DOI:10.1111/j.1600-0854.2009.01026.x

PMID:20070605

Abstract

In eukaryotes, coat protein complex II (COPII) proteins are involved in transporting cargo proteins from the endoplasmic reticulum (ER) to the Golgi apparatus. The COPII proteins, Sar1, Sec23/24, and Sec13/31 polymerize into a coat that gathers cargo proteins into a coated vesicle. Structures have been recently solved of individual COPII proteins, COPII proteins in complex with cargo, and higher-order COPII coat assemblies. In this review, we will summarize the latest developments in COPII structure and discuss how these structures shed light on the functional mechanisms of the COPII coat.

摘要

在真核生物中，衣壳蛋白复合物 II（COPII）蛋白参与将货物蛋白从内质网（ER）运输到高尔基体。COPII 蛋白 Sar1、Sec23/24 和 Sec13/31 聚合形成衣壳，将货物蛋白聚集到包被小泡中。最近已经解决了单个 COPII 蛋白、与货物复合的 COPII 蛋白以及更高阶 COPII 衣壳组装体的结构。在这篇综述中，我们将总结 COPII 结构的最新进展，并讨论这些结构如何阐明 COPII 衣壳的功能机制。