Graduate Program in Nutrition, Institute of Nutrition Josué de Castro, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Bone. 2010 Apr;46(4):957-63. doi: 10.1016/j.bone.2010.01.365. Epub 2010 Jan 13.
Birth weight is positively associated with adult bone mass. However, it is not clear if its effect is already evident in early adulthood.
To investigate the association between birth weight, adult body size, the interaction between them and bone mass in young adults.
Bone densitometry by DXA was performed on 496 individuals (240 men) aged 23-24 years from the 1978/79 Ribeirão Preto (southern Brazil) birth cohort, who were born and still residing in the city in 2002. Birth weight and length as well as adult weight and height were directly measured and converted to z-scores. The influence of birth weight and length, and adult weight and height on bone area (BA), bone mineral content (BMC) and bone mineral density (BMD) at the lumbar spine, proximal femur and femoral neck were investigated through simple and multiple linear regression models. Adjustments were made for sex, skin color, gestational age, physical activity level, smoking status and dietary consumption of protein, calcium and alcohol. Interaction terms between birth weight and adult weight, and birth length and adult height were tested.
Men in the highest tertile of birth weight distribution had greater BA and BMC at all three bone sites when compared with their counterparts in the lowest tertiles (p<0.008). For BMD, this trend was observed only in the lumbar spine. Adult weight and height were positively associated with BA and BMC at all three bone sites (p<0.05). For BMD, these associations were seen for adult weight, but for adult height an association was observed only in the lumbar spine. Birth weight retained positive associations with proximal femur BA and BMC after adjustments for current weight and height. No interaction was observed between variables measuring prenatal growth and adult body size.
Birth weight and postnatal growth are independent determinants of adult bone mass in a sample of Brazilian adults. This effect is already evident in early adulthood.
出生体重与成人骨量呈正相关。然而，其在成年早期是否有影响尚不清楚。
研究出生体重、成人身体大小、两者之间的相互作用与年轻人骨量之间的关系。
对 1978/79 年里贝朗普雷图（巴西南部）出生队列中 496 名（240 名男性）年龄在 23-24 岁的个体进行了 DXA 骨密度测定，这些个体出生时和 2002 年都居住在该城市。直接测量并将出生体重和长度以及成人体重和身高转换为 z 分数。通过简单和多元线性回归模型研究了出生体重和长度、成人体重和身高对腰椎、股骨近端和股骨颈骨面积（BA）、骨矿物质含量（BMC）和骨矿物质密度（BMD）的影响。调整了性别、肤色、胎龄、体力活动水平、吸烟状况和蛋白质、钙和酒精的饮食摄入量。测试了出生体重与成人体重和出生长度与成人身高之间的相互作用项。
出生体重分布最高三分位的男性在所有三个骨部位的 BA 和 BMC 均大于最低三分位的男性（p<0.008）。对于 BMD，这种趋势仅在腰椎中观察到。成人体重和身高与所有三个骨部位的 BA 和 BMC 呈正相关（p<0.05）。对于 BMD，成人体重与这些相关性相关，但成人身高仅在腰椎中观察到相关性。在调整当前体重和身高后，出生体重仍与股骨近端 BA 和 BMC 呈正相关。未观察到测量产前生长和成人身体大小的变量之间存在相互作用。
在巴西成年人样本中，出生体重和出生后生长是成人骨量的独立决定因素。这种影响在成年早期就已经存在。
