de Araújo Ubirajara Rutilio Mendes E Ferreira, Czeczko Nicolau Gregori, Ribas-Filho Jurandir Marcondes, Malafaia Osvaldo, Budel Vinícius Milani, Balderrama Cynthia Maria S Rojas, Zimmermann Elise, Dietz Ulrich Andreas
Evangelical Medical School, Curitiba, Paraná, Brazil.
Rev Col Bras Cir. 2009 Jul;36(3):241-9.
To compare the clinical and histological outcomes of the repair of induced abdominal wall defects with Parietex and Optilene Mesh Elastic + Safil in direct contact with abdominal viscera (intraperitoneal position, IPOM).
Sixteen rabbits were allocated into two groups with 8 animals each, corresponding to evaluation on the 30th and 60th postoperative days. All animals were submitted to two standardized symmetric abdominal wall defects, comprising all muscular layers and the peritoneum, followed by repair through the intraperitoneal placement of two different meshes. The experimental design allowed each animal to be its own control. Macroscopic aspects evaluated were: surgical site infection, mesh erosion, suture insufficiency, fistulae, intra-abdominal infection and adhesion formation. Microscopic parameters analyzed consisted of collagen deposition and the immunohistochemical healing process.
The formation of intraperitoneal adhesions and the other macroscopic outcome measures evaluated did not present significant statistical differences between the two meshes, neither did type I and III collagen deposition and MMP-1 and MMP-8 antibody expression. MMP-13 antibody exhibited significantly higher expression on the 30th postoperative day with Optilene+Safil and on the 60th day with Parietex.
Due to the similar results obtained, both macroscopically and microscopically, the meshes can be considered equivalent with respect to the healing of surgical wounds in abdominal wall defects in rabbits.
比较Parietex补片和Optilene Mesh Elastic + Safil补片直接与腹腔脏器接触（腹腔内位置，IPOM）修复诱导性腹壁缺损的临床和组织学结果。
将16只兔子分为两组，每组8只，分别在术后第30天和第60天进行评估。所有动物均造成两个标准化的对称腹壁缺损，包括所有肌层和腹膜，然后通过腹腔内放置两种不同的补片进行修复。实验设计允许每只动物作为自身对照。评估的宏观方面包括：手术部位感染、补片侵蚀、缝合不足、瘘管、腹腔内感染和粘连形成。分析的微观参数包括胶原蛋白沉积和免疫组化愈合过程。
两种补片在腹腔内粘连形成及其他评估的宏观结果指标方面均无显著统计学差异，I型和III型胶原蛋白沉积以及MMP-1和MMP-8抗体表达也无差异。MMP-13抗体在术后第30天Optilene+Safil组表达显著更高，在第60天Parietex组表达显著更高。
由于在宏观和微观上均获得了相似的结果，对于兔腹壁缺损手术伤口的愈合而言，两种补片可被视为等效。
