Misra S P, Dwivedi M, Mital M, Misra V
Gastroenterology Unit, Postgraduate Department of Medicine, M. L. N. Medical College, Allahabad, India.
J Clin Gastroenterol. 1991 Feb;13(1):65-8. doi: 10.1097/00004836-199102000-00014.
To assess whether gallbladder motility is altered in patients with irritable bowel syndrome (IBS) or essential dyspepsia (ED), we studied gallbladder function in 25 healthy volunteers, 20 patients with IBS, and 22 with ED. By real time ultrasonography, we studied the following parameters: (a) fasting gallbladder volume, (b) maximum percent of gallbladder emptied, (c) time required for maximal contraction, (d) residual volume after maximal contraction, and (e) percent fasting volume at 2 h. All parameters, except fasting gallbladder volume, were measured after a high-fat meal. The fasting gallbladder volume, maximum percent of gallbladder emptied, time required for maximal contraction, residual volume after maximal contraction, and percent fasting volume at 2 h in controls and patients with IBS was 19.3 +/- 8.8 ml and 24.4 +/- 9.7 ml, 67.1 +/- 10.7% and 67.6 +/- 13.5%, 41 +/- 20.6 min and 49.7 +/- 25.3 min, 6.2 +/- 3.3 ml and 7.6 +/- 5.3 ml, and 38.1 +/- 12.2% and 40.7 +/- 14.5%, respectively. The differences between the two groups were statistically not significant. The corresponding values in patients with ED were 15.5 +/- 6.3 ml, 57.6 +/- 16.5%, 51.8 +/- 29.3 min, 6.1 +/- 3.2 ml, 44.1 +/- 17%, respectively. Compared with controls there was no statistically significant difference in these parameters, except the maximum percent of gallbladder emptied, which was significantly less than that in controls (57.6 +/- 16.5% vs. 67.1 +/- 10.7%; p less than 0.05). Therefore, we could not find that patients with IBS have any abnormality of gallbladder function; postprandially, patients with ED have submaximal contraction of the gallbladder.
为评估肠易激综合征（IBS）或功能性消化不良（ED）患者的胆囊运动功能是否改变，我们对25名健康志愿者、20名IBS患者和22名ED患者的胆囊功能进行了研究。通过实时超声检查，我们研究了以下参数：（a）空腹胆囊容积；（b）胆囊排空的最大百分比；（c）最大收缩所需时间；（d）最大收缩后的残余容积；（e）2小时时的空腹容积百分比。除空腹胆囊容积外，所有参数均在高脂餐后测量。对照组和IBS患者的空腹胆囊容积、胆囊排空的最大百分比、最大收缩所需时间、最大收缩后的残余容积以及2小时时的空腹容积百分比分别为19.3±8.8 ml和24.4±9.7 ml、67.1±10.7%和67.6±13.5%、41±20.6分钟和49.7±25.3分钟、6.2±3.3 ml和7.6±5.3 ml、38.1±12.2%和40.7±14.5%。两组之间的差异无统计学意义。ED患者的相应值分别为15.5±6.3 ml、57.6±16.5%、51.8±29.3分钟、6.1±3.2 ml、44.1±17%。与对照组相比，除胆囊排空的最大百分比显著低于对照组（57.6±16.5%对67.1±10.7%；P<0.05）外，这些参数无统计学显著差异。因此，我们未发现IBS患者有任何胆囊功能异常；餐后，ED患者胆囊收缩不足。
