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[侵犯肺尖部肺癌的治疗策略与结果]

[Treatment strategy and outcomes of invading apical lung cancer].

作者信息

Toyooka Shinichi, Sou J, Sugimoto R, Yamane M, Oto T, Yoshimasu T, Okamura Y, Sano Y, Date H, Miyoshi S

机构信息

Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Okayama University, Japan.

出版信息

Kyobu Geka. 2010 Jan;63(1):57-64.

Abstract

Invading apical lung cancers are generally the non-small-cell lung cancers (NSCLCs) which involve the apex of the chest wall. These tumors should be classified into 2 types based on the main location of tumor because of the difference of involved surrounding structures ; (1) the superior sulcus tumor origi nally termed Pancoast tumor which involves posterior region of the apex and (2) the anterior apical tumor which involves anterior region of the apex. Previously, these NSCLCs were considered to be inoperable showing a dismal prognosis. With the development of combined modality therapies for locally advanced NSCLCs, the prognosis of invading apical NSCLCs has been improved, especially since intro duction of the neoadjuvant chemoradiotherapy. Surgical resection for invading apical NSCLCs is 1 of challenging procedures for thoracic surgeons. The point is the anatomical complication of the small apex surrounding vital structures. Several approaches have been developed such as the posterior Paul-son's approach or anterior Masaoka's approach. In particular, the approach from anterior chest has been modified or devised to achieve safe and complete resection of tumors invading anterior structures like subclavian vessels. In this article, we reviewed our 13 cases of invading apical NSCLCs, especially from the view point of surgical approach. Thoracic surgeons should understand the properties of each approach and master them for complete resection avoiding serious complications.

摘要

侵犯肺尖部的肺癌通常是非小细胞肺癌(NSCLC),累及胸壁尖部。由于所累及的周围结构不同,这些肿瘤应根据肿瘤的主要位置分为2型:(1)最初称为潘科斯特瘤的肺上沟瘤,累及肺尖后部;(2)累及肺尖前部的前肺尖肿瘤。以前,这些NSCLC被认为无法手术,预后很差。随着局部晚期NSCLC综合治疗方法的发展,侵犯肺尖NSCLC的预后得到了改善,尤其是自新辅助放化疗引入以来。侵犯肺尖NSCLC的手术切除是胸外科医生面临的具有挑战性的手术之一。关键在于肺尖小区域周围重要结构的解剖复杂性。已经开发了几种手术入路,如后保罗森入路或前正冈入路。特别是,前胸入路已经得到改进或设计,以实现对侵犯锁骨下血管等前部结构的肿瘤进行安全、完整的切除。在本文中,我们回顾了我们治疗的13例侵犯肺尖NSCLC病例,特别是从手术入路的角度。胸外科医生应该了解每种入路的特点并掌握它们,以便完整切除肿瘤并避免严重并发症。

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