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骨骼肌作为酒精和药物分析的替代样本。

Skeletal muscle as an alternative specimen for alcohol and drug analysis.

作者信息

Garriott J C

机构信息

Bexar County Medical Examiner's Office, Regional Crime Laboratory, San Antonio, TX.

出版信息

J Forensic Sci. 1991 Jan;36(1):60-9.

PMID:2007881
Abstract

In a random group of medical examiner cases, muscle tissue, as well as blood and vitreous humor, was analyzed for ethyl alcohol, and the results were compared. When the blood concentration was greater than 0.10 g/dL, the muscle to blood ratio was 1.00 or less (average 0.94), and when the blood concentration was less than 0.10 g/dL, this ratio was greater than 1.00 (average 1.48). The author proposes that this ratio is dependent upon the time course of absorption and distribution, as has been observed for vitreous humor, but with a more rapid equilibration. Muscle tissue was also analyzed in another group of cases found to be positive for one or more drugs in blood. The concentrations of the drugs in muscle varied from none detected to 6.5 times those in blood and seemed to be dependent on the time course between ingestion and death, as well as on the nature of the drug. For most common basic drugs, the ratios were often near unity. Muscle is proposed as a useful alternative specimen to postmortem blood.

摘要

在一组随机选取的法医案例中,对肌肉组织以及血液和玻璃体液进行了乙醇分析,并对结果进行了比较。当血液浓度大于0.10 g/dL时,肌肉与血液的比率为1.00或更低(平均为0.94),而当血液浓度小于0.10 g/dL时,该比率大于1.00(平均为1.48)。作者提出,该比率取决于吸收和分布的时间进程,正如在玻璃体液中所观察到的那样,但平衡过程更快。在另一组血液中发现一种或多种药物呈阳性的案例中,也对肌肉组织进行了分析。肌肉中药物的浓度从未检测到到血液中浓度的6.5倍不等,似乎取决于摄入与死亡之间的时间进程以及药物的性质。对于大多数常见的碱性药物,比率通常接近1。肌肉被提议作为死后血液的一种有用替代样本。

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