GGZ inGeest, Amsterdam, The Netherlands.
J Affect Disord. 2010 Sep;125(1-3):330-5. doi: 10.1016/j.jad.2009.12.004. Epub 2010 Jan 15.
Cognitive impairment in elderly bipolar patients persists during euthymic state, yet the aetiology of such impairment is not well understood. The objective of this study is to identify factors contributing to cognitive impairment in elderly patients with bipolar disorder.
119 older patients (age >60) with bipolar I or II disorder in a euthymic state were extensively tested on cognitive functioning including attention, memory, visuoconstruction, executive function and verbal fluency with regard to potential risk factors.
Regression analysis shows that health related factors, medication and illness characteristics are associated with cognitive impairment in several cognitive domains: attention, memory, visuoconstruction, executive function and verbal fluency. More vascular burden factors are related to poorer outcome of cognitive functioning. Patients with lithium pharmacotherapy performed worse compared to those with other mood stabilizers, but this was no longer significant in multivariate analysis.
In elderly bipolar patients, more vascular risk factors and more hospital admissions are associated with more cognitive impairment.
老年双相情感障碍患者在病情稳定期仍存在认知障碍，但这种认知障碍的病因尚不清楚。本研究旨在确定导致老年双相情感障碍患者认知障碍的因素。
对 119 名处于病情稳定期的老年（年龄>60 岁）I 型或 II 型双相情感障碍患者进行了广泛的认知功能测试，包括注意力、记忆、视觉构建、执行功能和言语流畅性，以评估潜在的风险因素。
回归分析表明，健康相关因素、药物和疾病特征与注意力、记忆、视觉构建、执行功能和言语流畅性等多个认知领域的认知障碍有关。更多的血管负担因素与认知功能的预后较差有关。锂治疗的患者与其他情绪稳定剂相比表现更差，但在多变量分析中这一差异不再显著。
在老年双相情感障碍患者中，更多的血管危险因素和更多的住院治疗与更多的认知障碍有关。
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