Centro Studi Gruppo Italiano Studi Epidemiologici in Dermatologia and Department of Dermatology, Largo Barozzi 1, Ospedali Riuniti, 24100 Bergamo, Italy.
Clin Dermatol. 2010 Jan-Feb;28(1):88-92. doi: 10.1016/j.clindermatol.2009.03.003.
Cancer is one of the several comorbidities that have been linked with psoriasis. Not surprisingly, tumors associated with well-documented risk factors for the dermatosis, such as smoking and obesity, have been found with increased incidence in psoriatic patients. They include lung, kidney, and colon cancers. For unknown reasons, the risk of lymphoma is also increased in psoriatic patients. Despite several difficulties with documenting risks, some systemic treatments for psoriasis have been linked with an increased risk of selected cancers. The best-documented association is nonmelanoma skin cancer with psoralen plus ultraviolet A therapy and cyclosporin. More recently, an increased risk of cancer has been a concern with newly introduced biologic agents. The documentation of such a purported increased risk requires long-term follow-up of treated patients.
癌症是与银屑病相关的几种合并症之一。毫不奇怪，与该皮肤病有明确记录的风险因素相关的肿瘤，如吸烟和肥胖，在银屑病患者中发病率增加。这些肿瘤包括肺癌、肾癌和结肠癌。由于未知原因，淋巴瘤的风险在银屑病患者中也增加。尽管在记录风险方面存在一些困难，但一些用于治疗银屑病的系统治疗方法与某些癌症的风险增加有关。最有文献记载的关联是非黑素瘤皮肤癌与补骨脂素加紫外线 A 疗法和环孢素有关。最近，新引入的生物制剂引起了人们对癌症风险增加的关注。这种所谓的风险增加的记录需要对接受治疗的患者进行长期随访。
