Ma Fu-Bao, Tao Hong, Wang Hong-Jun
Jiangsu Province Center for Disease Control and Prevention, Nanjing 210009, Jiangsu, China.
Zhongguo Yi Miao He Mian Yi. 2009 Oct;15(5):451-5.
To evaluate the Immunogenicity of Group A and Group C Meningococcal conjugate Vaccine with coupling Group B Meningococcal Outer Membrane Protein (Men B-OMP).
458 healthy children aged 3-5 months, 6-23 months, 2-6 years and 7-24 years were given the Groups A and C conjugate Vaccine with MenB-OMP or other vaccine as control group to measure the pre-and post-vaccination Men A and C and B by Serum Bactericidal Assay (SBA) in the double-blind randomized controlled trial.
97.65%-100% were 4 times or greater increase in SBA titer for the healthy children given the Groups A and C conjugate Vaccine with MenB-OMP, The geometric mean titer of SBA were 1:194-1:420, which significantly higber than controls.
The Group A and C conjugate Vaccine with MenB-OMP was safe and well immunogenic.
评估A群和C群脑膜炎球菌结合疫苗与B群脑膜炎球菌外膜蛋白（Men B - OMP）偶联后的免疫原性。
在双盲随机对照试验中，将458名年龄在3至5个月、6至23个月、2至6岁和7至24岁的健康儿童接种含MenB - OMP的A群和C群结合疫苗或其他疫苗作为对照组，通过血清杀菌试验（SBA）测量接种疫苗前后的A、C和B群抗体。
接种含MenB - OMP的A群和C群结合疫苗的健康儿童中，97.65% - 100%的SBA效价升高4倍或更高，SBA几何平均效价为1:194 - 1:420，显著高于对照组。
含MenB - OMP的A群和C群结合疫苗安全且免疫原性良好。
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