Gene Regulation Programme, Centre de Regulació Genòmica (CRG-UPF), Barcelona, Spain.
Bioessays. 2010 Feb;32(2):109-18. doi: 10.1002/bies.200900122.
Cold shock domain (CSD)-containing proteins have been found in all three domains of life and function in a variety of processes that are related, for the most part, to post-transcriptional gene regulation. The CSD is an ancient beta-barrel fold that serves to bind nucleic acids. The CSD is structurally and functionally similar to the S1 domain, a fold with otherwise unrelated primary sequence. The flexibility of the CSD/S1 domain for RNA recognition confers an enormous functional versatility to the proteins that contain them. This review summarizes the current knowledge on eukaryotic CSD/S1 domain-containing proteins with a special emphasis on UNR (upstream of N-ras), a member of this family with multiple copies of the CSD.
冷休克结构域（CSD）蛋白在所有三个生命领域都有发现，它们在多种过程中发挥作用，这些过程在很大程度上与转录后基因调控有关。CSD 是一种古老的β桶折叠结构，用于结合核酸。CSD 在结构和功能上与 S1 结构域相似，后者的一级序列没有其他关系。CSD/S1 结构域的 RNA 识别灵活性赋予了包含它们的蛋白质巨大的功能多样性。这篇综述总结了真核生物 CSD/S1 结构域蛋白的最新知识，特别强调了 UNR（N-ras 上游），这是该家族中具有多个 CSD 拷贝的成员。
