HIV 女性儿童的病理学。

Pathology in children of HIV women.

机构信息

Servicio Inmuno-Pediatría, Hospital Universitario La Paz, Madrid, Spain.

出版信息

Indian J Pediatr. 2009 Nov;76(11):1125-30. doi: 10.1007/s12098-009-0225-8.

DOI:10.1007/s12098-009-0225-8

PMID:20092024

Abstract

OBJECTIVE

To assess the frequency of perinatal pathology in children exposed to antiretrovirals in perinatal period.

DESIGN

Retrospective observational cohort study.

METHODS

Retrospective observational cohort study. Data collected among uninfected children born to HIV-infected women followed up from 1994 to 2006 in a tertiary Hospital. 220 uninfected children were studied. Factors studied included maternal, obstetrical and pediatric variables.

RESULTS

The most common disorder found among children exposed to antiretroviral drugs was anemia (84%); 6,4% of children had neutropenia and more than 24% had thrombocytosis, a finding never described before. Prematurity (24%) and low birth weight (23.6%) rates were high. Several congenital malformations were found: Poland syndrome, angiomas, hypospadias, Pierre-Robin sequence, trisomy 8, craniostosis and others. Long-term follow-up revealed neurological, cardiological and ophthalmological pathologies.

CONCLUSION

Some pathologies are frequent among children exposed to antiretroviral agents during perinatal life. It is crucial to carry out long-term studies to assess the safety of this therapy.

摘要

目的

评估围产期暴露于抗逆转录病毒药物的儿童的围产期病理学发生率。

设计

回顾性观察性队列研究。

方法

回顾性观察性队列研究。本研究的数据收集自 1994 年至 2006 年期间在一家三级医院接受随访的 HIV 感染母亲所生的未感染儿童。共研究了 220 名未感染的儿童。研究的因素包括母婴、产科和儿科变量。

结果

在接受抗逆转录病毒药物治疗的儿童中，最常见的疾病是贫血（84%）；6.4%的儿童中性粒细胞减少，超过 24%的儿童血小板增多，这是以前从未描述过的发现。早产（24%）和低出生体重（23.6%）的发生率较高。发现了一些先天性畸形：波兰综合征、血管瘤、尿道下裂、Robin 序列、8 三体、颅缝早闭等。长期随访发现了神经、心脏和眼科的病变。