Liang Xiaobing, Liu Xishun, Liu Anzhi, Wang Boliang
School of Electronic Science and Engineering, National University of Defense Technology, Changsha 410073, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2009 Dec;26(6):1241-5.
We have investigated the effects of high frequency (HF) signal on firing activity in a biologically realistic system--the noisy Hodgkin-Huxley (HH) neuron model via numerical simulations. The results show that when the HF amplitude to frequency ratio (AFR) increases, the firing rate is diminished and stochastic resonance disappears, even the HH neuron model is processing a stimulus of its most sensitive frequency. When the noise intensity is strong, the vibration resonance can be observed. Moreover, the fluctuation around the resting potential will be replaced by an oscillation of the same high frequency with the increasing AFR. The inhibition of the firing activity is consistent with the results of experiment in vivo that HF current can stop the transmission of action potential in peripheral nerve. This study is of functional significance to the biomedical research on the damages caused by electro-pollution in vivo and signal processing.
我们通过数值模拟研究了高频（HF）信号对生物现实系统——有噪声的霍奇金-赫胥黎（HH）神经元模型放电活动的影响。结果表明，当高频幅度与频率比（AFR）增加时，放电率降低且随机共振消失，即使HH神经元模型正在处理其最敏感频率的刺激。当噪声强度较大时，可以观察到振动共振。此外，随着AFR的增加，静息电位附近的波动将被相同高频的振荡所取代。放电活动的抑制与体内实验结果一致，即高频电流可阻止外周神经中动作电位的传递。本研究对于体内电污染造成的损伤及信号处理的生物医学研究具有功能意义。
