镍基混合配体体系催化的芳基甲磺酸酯和对甲苯磺酸酯的新戊二醇硼化反应，该体系通过 Zn 活化。
Neopentylglycolborylation of aryl mesylates and tosylates catalyzed by Ni-based mixed-ligand systems activated with Zn.
机构信息
Roy & Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, USA.
出版信息
J Am Chem Soc. 2010 Feb 17;132(6):1800-1. doi: 10.1021/ja910808x.
PMID:20095554
Abstract
The mixed-ligand system NiCl(2)(dppp)/dppf is shown to be an effective catalyst for the neopentylglycolborylation of ortho-, meta-, and para-substituted electron-rich and electron-deficient aryl mesylates and tosylates. The addition of Zn powder as a reductant dramatically increases the reaction yield and reduces the reaction time by more than an order of magnitude, providing complete conversion in 1-3 h.
摘要
混合配体体系 NiCl(2)(dppp)/dppf 被证明是一种有效的催化剂，可用于邻位、间位和对位取代的富电子和缺电子芳基甲磺酸酯和甲苯磺酸酯的新戊二醇硼化反应。添加 Zn 粉作为还原剂可显著提高反应产率，并将反应时间缩短一个数量级以上，在 1-3 h 内可实现完全转化。
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