Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Immunopharmacol Immunotoxicol. 2010 Jun;32(2):327-32. doi: 10.3109/08923970903349281.
We investigated the effect of topical application of Brazilian propolis on scratching behavior induced by compound 48/80 in mice.
Propolis inhibited compound 48/80-induced scratching behavior when applied immediately after treatment with propolis at a dose of 3 mg/site. Dibucaine 0.3 mg/site also significantly inhibited compound 48/80-induced scratching behavior immediately after application. On the other hand, propolis inhibited compound 48/80-induced scratching behavior even 15, 30 and 60 min after application; however, dibucaine showed no significant inhibition of compound 48/80-induced scratching behavior 15, 30 and 60 min after application. In addition, propolis had no effect on increased vascular permeability just after application, but the drug had a significant effect 15, 30 and 60 min after application. On the contrary, histamine-induced scratching behavior was inhibited significantly by propolis just after application. On the other hand, propolis significantly inhibited histamine release from rat mast cells induced by compound 48/80 at a concentration of more than 10 microg/ml.
From these results, it can be concluded that inhibition of scratching behavior induced by topical application occurred by both its local anesthetic and systemic action through inhibition of histamine release.
我们研究了巴西蜂胶局部应用对 48/80 混合物诱导的小鼠搔抓行为的影响。
蜂胶在以 3mg/部位的剂量在施用蜂胶后立即处理时抑制了 48/80 混合物诱导的搔抓行为。布比卡因 0.3mg/部位在施用后也立即显著抑制了 48/80 混合物诱导的搔抓行为。另一方面，蜂胶抑制了 48/80 混合物诱导的搔抓行为，即使在施用后 15、30 和 60 分钟也是如此；然而，布比卡因在施用后 15、30 和 60 分钟时对 48/80 混合物诱导的搔抓行为没有显著抑制作用。此外，蜂胶对施用后即刻增加的血管通透性没有影响，但在施用后 15、30 和 60 分钟时具有显著作用。相反，蜂胶在施用后即刻显著抑制了组织胺诱导的搔抓行为。另一方面，蜂胶在 10μg/ml 以上的浓度下显著抑制了 48/80 混合物诱导的大鼠肥大细胞中组织胺的释放。
从这些结果可以得出结论，通过抑制组织胺释放，通过局部麻醉和全身作用抑制了由局部应用引起的搔抓行为。
Zotero 插件