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[系统性淀粉样变性：实用诊断]

[Systemic amyloidosis: practical diagnosis].

作者信息

Noël Laure-Hélène

机构信息

Inserm U 845, hôpital Necker, 161, rue de Sèvres, 75015 Paris, France.

出版信息

Nephrol Ther. 2010 Apr;6(2):88-96. doi: 10.1016/j.nephro.2009.10.002. Epub 2010 Jan 22.

DOI:10.1016/j.nephro.2009.10.002

PMID:20097147

Abstract

Amyloid deposits have particular ultrastructural appearance with 7 to 10 nm-diameter fibrils. Amyloid is defined by its tinctorial affinity, which includes Congo red positivity, which must polarize and produce apple-green birefringence. Immunohistochemical characterization allows to know the origin of amyloidosis (characterization, which must be performed on frozen tissue). This restatement is proposed to renal pathologists in indicating the traps of studying amyloidosis, the tissues performing for the diagnosis, the specific staining and the immunohistochemical characterization.

摘要

淀粉样沉积物具有特定的超微结构外观，其纤维直径为7至10纳米。淀粉样物质由其染色亲和力定义，包括刚果红阳性，刚果红阳性必须发生偏振并产生苹果绿双折射。免疫组织化学特征有助于了解淀粉样变性的起源（该特征必须在冷冻组织上进行）。本声明旨在向肾脏病理学家指出研究淀粉样变性的陷阱、用于诊断的组织、特异性染色以及免疫组织化学特征。