Shijo H, Sasaki H, Yuh K, Sakaguchi S, Okumura M
First Department of Internal Medicine, School of Medicine, Fukuoka University, Japan.
Chest. 1991 Apr;99(4):1027-9. doi: 10.1378/chest.99.4.1027.
A patient had liver cirrhosis associated with marked hypoxemia. With administration of indomethacin (75 mg/day for six days), PaO2 was elevated up to 50 mm Hg from 44 mm Hg. At that time, dynamic pulmonary perfusion imaging revealed a plateau time course curve of MAA uptake in the lungs, as compared with findings obtained during the state of severe hypoxemia without indomethacin. These observations suggest that part of hepatogenic pulmonary angiodysplasia is a functional vasodilatation that is presumably modulated by vasoactive substances, such as prostaglandins and/or other eicosanoids.
一名患有肝硬化并伴有明显低氧血症的患者。给予吲哚美辛（75毫克/天，共6天）后，动脉血氧分压（PaO2）从44毫米汞柱升至50毫米汞柱。此时，动态肺灌注显像显示，与未使用吲哚美辛的严重低氧血症状态下的结果相比，肺部巨聚白蛋白（MAA）摄取呈平台期时程曲线。这些观察结果表明，部分肝源性肺血管发育异常是一种功能性血管舒张，可能受血管活性物质如前列腺素和/或其他类二十烷酸调节。
