伴惊恐-广场恐惧症共病对住院抑郁症患者自杀的影响。
The impact of panic-agoraphobic comorbidity on suicidality in hospitalized patients with major depression.
机构信息
Psychosocial Research Program, Butler Hospital, 345 Blackstone Boulevard, Providence, RI 02906, USA.
出版信息
Depress Anxiety. 2010 Mar;27(3):310-5. doi: 10.1002/da.20609.
BACKGROUND
Previous research in outpatient samples suggests that panic and agoraphobic comorbidity is related to suicidality in outpatients with major depression. The purpose of the study was to further investigate this relationship specifically in a hospitalized sample.
METHOD
This study examined the severity of current suicidal ideation and behaviors in a psychiatric hospital sample diagnosed with major depressive disorder alone (MDD; n=28) versus MDD plus panic-agoraphobic spectrum disorders (MDD+PAS; n=69).
RESULTS
Members of the MDD+PAS group were significantly more likely to have had a suicide attempt history, higher current depression severity, and higher current suicidal severity compared with individuals in the MDD alone group. The relationship between the current suicidality and comorbid PAS remained significant after controlling for the overall depression severity and other clinical factors.
CONCLUSIONS
These findings suggest that panic-agoraphobic comorbidity is associated with a greater risk for suicidality in hospitalized patients, which cannot be adequately explained by the level of current depression alone. The clinical and research implications for these findings are discussed.
背景
先前在门诊样本中的研究表明，惊恐和广场恐怖共病与门诊重度抑郁症患者的自杀意念有关。本研究的目的是专门在住院患者样本中进一步研究这种关系。
方法
本研究在被诊断为单纯重度抑郁症（MDD；n=28）与 MDD 加惊恐-广场恐怖谱系障碍（MDD+PAS；n=69）的精神病院患者样本中，调查了当前自杀意念和行为的严重程度。
结果
与单纯 MDD 组相比，MDD+PAS 组的自杀尝试史、当前抑郁严重程度和当前自杀严重程度显著更高。在控制总体抑郁严重程度和其他临床因素后，当前自杀意念与共患 PAS 之间的关系仍然显著。
结论
这些发现表明，惊恐-广场恐怖共病与住院患者自杀意念的风险增加有关，这不能仅用当前抑郁的程度来充分解释。讨论了这些发现的临床和研究意义。
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