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伴有真菌致敏的重度哮喘:一例病例报告及文献综述

Severe asthma with fungal sensitization: a case report and review of literature.

作者信息

Madani Yasser, Barlow Andrew, Taher Furqan

机构信息

Department of Respiratory Medicine, Watford General Hospital, Watford, Hertfordshire, WD18 0HB, United Kingdom.

出版信息

J Asthma. 2010 Feb;47(1):2-6. doi: 10.3109/02770900903362684.

Abstract

There is a substantial body of evidence supporting an association between asthma severity and fungal exposure and sensitization. Fungal allergens are a recognized risk factor for severe asthma. We describe the case of a 44-year-old asthmatic whose asthma control deteriorated after moving to a new flat with walls covered in mould. Allergic bronchopulmonary aspergillosis was excluded. Although sensitization to Candida was demonstrated by a positive Candida-specific radioallergosorbent test, the patient did not entirely satisfy the criteria for a diagnosis of allergic bronchopulmonary candidiasis. The patient's asthma control improved after engaging in a monthly washing regimen of the walls. This case further demonstrates the association between fungal sensitization and asthma severity. The term severe asthma with fungal sensitization has been recently coined to describe this phenomenon.

摘要

有大量证据支持哮喘严重程度与真菌暴露及致敏之间存在关联。真菌过敏原是重度哮喘公认的危险因素。我们描述了一名44岁哮喘患者的病例,该患者搬到一个墙壁长满霉菌的新公寓后,哮喘控制情况恶化。已排除变应性支气管肺曲霉病。尽管念珠菌特异性放射变应原吸附试验呈阳性表明对念珠菌致敏,但该患者并不完全符合变应性支气管肺念珠菌病的诊断标准。患者在每月对墙壁进行清洁处理后,哮喘控制情况有所改善。该病例进一步证明了真菌致敏与哮喘严重程度之间的关联。最近创造了“真菌致敏性重度哮喘”这一术语来描述这一现象。

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