Department of Dermatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Dermatol Surg. 2010 Mar;36(3):368-76. doi: 10.1111/j.1524-4725.2009.01447.x. Epub 2010 Jan 19.
An association exists between chronic lymphocytic leukemia and malignant melanoma.
To study the clinical behavior of malignant melanoma in patients with chronic lymphocytic leukemia.
A retrospective chart review was conducted of patients with chronic lymphocytic leukemia and malignant melanoma.
Sixty-nine patients had malignant melanoma and chronic lymphocytic leukemia. The recurrence-free and metastasis-free survival rates at 2, 5, and 10 years were 93.4% and 89.1%, 83.8% and 93.4%, and 87.4% and 82.1%, respectively. No significant difference was observed in age- and sex-adjusted mortality rates between patients with chronic lymphocytic leukemia diagnosed before malignant melanoma and those with chronic lymphocytic leukemia diagnosed after malignant melanoma.
Retrospective study and small patient population.
Patients with malignant melanoma and chronic lymphocytic leukemia were not shown to have worse survival rates than those with stage IA, IB, and IIA disease. Further research and prospective study are needed.
慢性淋巴细胞白血病与恶性黑色素瘤之间存在关联。
研究慢性淋巴细胞白血病患者中恶性黑色素瘤的临床行为。
对患有慢性淋巴细胞白血病和恶性黑色素瘤的患者进行了回顾性图表审查。
69 例患者同时患有恶性黑色素瘤和慢性淋巴细胞白血病。2、5 和 10 年无复发生存率和无转移生存率分别为 93.4%和 89.1%、83.8%和 93.4%以及 87.4%和 82.1%。在年龄和性别调整后的死亡率方面，在恶性黑色素瘤之前被诊断为慢性淋巴细胞白血病的患者与在恶性黑色素瘤之后被诊断为慢性淋巴细胞白血病的患者之间没有显著差异。
回顾性研究和小患者人群。
与 IA 期、IB 期和 IIA 期疾病相比，患有恶性黑色素瘤和慢性淋巴细胞白血病的患者的生存率并未显示出更差。需要进一步的研究和前瞻性研究。
