Kidher Emaddin, Sepehripour Amir, Punjabi Prakash, Athanasiou Thanos
Department of Surgery and Cancer, Imperial College London, London, UK.
Interact Cardiovasc Thorac Surg. 2010 Apr;10(4):605-10. doi: 10.1510/icvts.2009.228593. Epub 2010 Jan 25.
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether there is a relationship between hospital or surgeon volume (SV) and postoperative outcome in adult aortic or mitral valve surgery. One hundred and sixty papers were found using the specified search strategy, of which seven papers represented the best evidence to answer this question. The author, journal, date and country of publication, patient group studied, study type, relevant outcomes, methodology scores, study weaknesses and results are tabulated. Outcomes assessed by these studies were variable; four papers used mortality, one paper used morbidity, one paper used care processes and one paper examined all the above-mentioned outcomes. Six papers investigated the effect of hospital volume (HV) on outcome whilst only one paper assessed the effect of both HV and SV on outcome. The type of valve operated on was also mixed; two papers studied aortic valve only, one paper studied mitral valve only and four papers studied both valves. The methodological quality and validity of each study was assessed by a predefined scoring system. The median total quality score was modest and not strong enough to support the conclusions reported by these studies. In addition, volume-outcome relationship can be affected by several factors related to patient, surgeon and hospital. These factors have not been considered in depth by the mentioned papers. However, there may be a positive relationship between hospital procedural volume and mortality which is more likely to be mediated by SV, and there is also a potential relationship with the rate of mitral valve repair and the use of bio-prosthetic valves in elderly patients. We conclude that regionalisation of adult aortic or mitral valve surgery based on such a limited number of modest quality studies would be an indefensible policy. The implementation of such a scheme can have many clinical, practical, economical and political consequences which have not been examined prospectively until today. Furthermore, the relationship between volume and other outcomes rather than mortality needs further assessment.
根据结构化方案撰写了一篇心脏外科的最佳证据主题文章。所探讨的问题是,在成人主动脉或二尖瓣手术中,医院或外科医生手术量(SV)与术后结果之间是否存在关联。使用特定的检索策略找到了160篇论文,其中7篇论文代表了回答该问题的最佳证据。现将作者、期刊、出版日期和国家、所研究的患者群体、研究类型、相关结果、方法学评分、研究不足及结果制成表格。这些研究评估的结果各不相同;4篇论文使用死亡率,1篇论文使用发病率,1篇论文使用护理过程,1篇论文考察了上述所有结果。6篇论文研究了医院手术量(HV)对结果的影响,而只有1篇论文评估了HV和SV对结果的综合影响。所手术的瓣膜类型也各不相同;2篇论文仅研究主动脉瓣,1篇论文仅研究二尖瓣,4篇论文研究了两种瓣膜。通过预定义的评分系统评估了每项研究的方法学质量和有效性。总质量评分中位数适中,不足以有力支持这些研究所报告的结论。此外,手术量与结果的关系可能会受到与患者、外科医生和医院相关的多种因素影响。上述论文尚未深入考虑这些因素。然而,医院手术量与死亡率之间可能存在正相关,这种关系更可能由SV介导,并且在老年患者中,手术量与二尖瓣修复率及生物瓣膜的使用之间也可能存在潜在关系。我们得出结论,基于如此有限数量的质量一般的研究对成人主动脉或二尖瓣手术进行区域化是一项不合理的政策。实施这样一个方案可能会产生许多临床实践、经济和政治后果,而直到如今尚未进行前瞻性研究。此外,手术量与死亡率之外的其他结果之间的关系需要进一步评估。