Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Neurology. 2010 Jan 26;74(4):306-12. doi: 10.1212/WNL.0b013e3181cbcd6f.
Many survivors of cardiac arrest are left with considerable long-term impairments due to a transient ischemic state of the brain. Neuropsychologists identified a wide range of neuropsychological deficits in these patients besides the well-known amnesic syndrome. To date, there is no complete and unbiased documentation of the affected brain areas in vivo. We aimed to identify the brain tissue atrophy underlying the observed neuropsychological deficits in a case-control study.
We measured gray matter loss by voxel-based morphometry of 3-T structural magnetic resonance images in a sample of 12 patients who had had cardiac arrest with successful subsequent resuscitation in comparison with 12 individually age- and sex-matched control subjects. Such data are rare because many of these patients wear cardiac pacemakers.
We found extensive reductions of gray matter volumes in the anterior, medial, and posterior cingulate cortex, the precuneus, the insular cortex, the posterior hippocampus, and the dorsomedial thalamus in tight correlation with neuropsychological impairments, namely, amnestic deficits and apathy.
The identified neuroanatomical pattern of brain tissue loss substantiates the reports of wide-ranging neuropsychological impairments in patients after cardiac arrest.
许多心脏骤停幸存者由于脑短暂性缺血状态而留下严重的长期损害。神经心理学家在这些患者中发现了除了众所周知的健忘症综合征以外的广泛的神经心理学缺陷。迄今为止，尚无关于体内受影响的脑区的完整和无偏的文献记录。我们旨在通过对 12 名成功复苏的心脏骤停患者和 12 名年龄和性别匹配的对照组的 3-T 结构磁共振成像的基于体素的形态计量学来测量灰质丢失，以确定观察到的神经心理学缺陷的基础。
我们发现，在与神经心理学缺陷（即健忘症和冷漠）密切相关的前扣带回、内侧和后扣带回皮质、楔前叶、岛叶、后海马和背内侧丘脑中，灰质体积广泛减少。
所识别的脑组织丢失的神经解剖模式证实了心脏骤停后患者广泛的神经心理学缺陷的报告。
