Urology and Nephrology Centre, University of Mansoura, Mansoura, Egypt.
Clin Exp Nephrol. 2010 Apr;14(2):152-7. doi: 10.1007/s10157-009-0261-8. Epub 2010 Jan 26.
Inflammation has been associated with atherosclerotic cardiovascular disease (CVD) and anemia in patients with end-stage renal disease (ESRD) which may lead to left ventricular impairment via myocardial hypertrophy and/or ischemia. We therefore sought to investigate serum levels of sFas in uremic patients and its correlation with known markers of inflammation and CVD.
The study included 30 patients on hemodialysis, 30 patients with chronic kidney disease (CKD), and 30 normal control subjects. We measured serum levels of sFas, C-reactive protein (CRP), and albumin. We also investigated the association of serum sFas levels with the presence of CVD by echocardiographic assessment before and after 1 year.
Levels of sFas were elevated in CKD and ESRD patients compared to controls. sFas levels correlated positively with serum creatinine and negatively with serum albumin. In the dialysis patients, we observed that sFas levels were higher among those with CVD. Compared with baseline, after 1 year of follow-up there was a significant decrease in left ventricular (LV) ejection fraction, increases in LV end-diastolic dimension and LV end-systolic dimension, and myocardial ischemic changes.
These results suggest that sFas may be a marker of inflammation in CKD and ESRD patients.
炎症与终末期肾病（ESRD）患者的动脉粥样硬化性心血管疾病（CVD）和贫血有关，这可能通过心肌肥厚和/或缺血导致左心室损伤。因此，我们试图研究尿毒症患者血清 sFas 水平及其与炎症和 CVD 的已知标志物的相关性。
本研究纳入 30 名血液透析患者、30 名慢性肾脏病（CKD）患者和 30 名正常对照者。我们测量了血清 sFas、C 反应蛋白（CRP）和白蛋白水平。我们还通过超声心动图评估，在 1 年后，调查了血清 sFas 水平与 CVD 之间的相关性。
与对照组相比，CKD 和 ESRD 患者的 sFas 水平升高。sFas 水平与血清肌酐呈正相关，与血清白蛋白呈负相关。在透析患者中，我们观察到 CVD 患者的 sFas 水平更高。与基线相比，1 年随访后，左心室（LV）射血分数显著降低，LV 舒张末期内径和 LV 收缩末期内径增加，心肌缺血改变。
这些结果表明，sFas 可能是 CKD 和 ESRD 患者炎症的标志物。
