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Use of enantiomeric bupropion and hydroxybupropion to assess CYP2B6 activity in glomerular kidney diseases.
J Clin Pharmacol. 2010 Jun;50(6):714-20. doi: 10.1177/0091270009353031. Epub 2010 Jan 26.
2
Efavirenz induces CYP2B6-mediated hydroxylation of bupropion in healthy subjects.
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Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity.
J Clin Pharmacol. 2008 Apr;48(4):464-74. doi: 10.1177/0091270008314254. Epub 2008 Feb 20.
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CYP2B6 and bupropion's smoking-cessation pharmacology: the role of hydroxybupropion.
Clin Pharmacol Ther. 2012 Dec;92(6):771-7. doi: 10.1038/clpt.2012.186. Epub 2012 Nov 14.
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Rapid clinical induction of bupropion hydroxylation by metamizole in healthy Chinese men.
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Effects of sertraline on the pharmacokinetics of bupropion and its major metabolite, hydroxybupropion, in mice.
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The influence of sex, ethnicity, and CYP2B6 genotype on bupropion metabolism as an index of hepatic CYP2B6 activity in humans.
Drug Metab Dispos. 2013 Mar;41(3):575-81. doi: 10.1124/dmd.112.048108. Epub 2012 Dec 13.

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Chirality of antidepressive drugs: an overview of stereoselectivity.
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The effect of chronic kidney disease on CYP2B expression and activity in male Wistar rats.
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3
Development and validation of a high-throughput stereoselective LC-MS/MS assay for bupropion, hydroxybupropion, erythrohydrobupropion, and threohydrobupropion in human plasma.
J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Apr 1;1017-1018:101-113. doi: 10.1016/j.jchromb.2016.02.032. Epub 2016 Feb 27.
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A Synopsis of Clinical Pharmacokinetic Alterations in Advanced CKD.
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In vivo alterations in drug metabolism and transport pathways in patients with chronic kidney diseases.
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本文引用的文献

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Pharmacokinetics of mycophenolic acid in patients with lupus nephritis.
Pharmacotherapy. 2009 Jan;29(1):7-16. doi: 10.1592/phco.29.1.7.
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Induction of cytochrome P450 2B6 activity by the herbal medicine baicalin as measured by bupropion hydroxylation.
Eur J Clin Pharmacol. 2009 Apr;65(4):403-9. doi: 10.1007/s00228-008-0594-3. Epub 2008 Dec 9.
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Downregulation of hepatic acetylation of drugs in chronic renal failure.
J Am Soc Nephrol. 2008 Jul;19(7):1352-9. doi: 10.1681/ASN.2007090974. Epub 2008 Apr 16.
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Emerging evidence of the impact of kidney disease on drug metabolism and transport.
Clin Pharmacol Ther. 2008 Jun;83(6):898-903. doi: 10.1038/clpt.2008.59. Epub 2008 Apr 2.
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Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity.
J Clin Pharmacol. 2008 Apr;48(4):464-74. doi: 10.1177/0091270008314254. Epub 2008 Feb 20.
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Stereoselective metabolism of bupropion by cytochrome P4502B6 (CYP2B6) and human liver microsomes.
Pharm Res. 2008 Jun;25(6):1405-11. doi: 10.1007/s11095-008-9535-1.
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Prevalence of chronic kidney disease in the United States.
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Effects of chronic renal failure on liver drug transporters.
Drug Metab Dispos. 2008 Jan;36(1):124-8. doi: 10.1124/dmd.107.018192. Epub 2007 Oct 16.
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Stereoselective analysis of bupropion and hydroxybupropion in human plasma and urine by LC/MS/MS.
J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Sep 15;857(1):67-75. doi: 10.1016/j.jchromb.2007.07.007. Epub 2007 Jul 10.
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Effect of renal impairment on the pharmacokinetics of bupropion and its metabolites.
Br J Clin Pharmacol. 2007 Aug;64(2):165-73. doi: 10.1111/j.1365-2125.2007.02866.x. Epub 2007 Mar 1.

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