儿童胫骨远端侵袭性肿瘤的踝关节切除关节融合术。

Resection arthrodesis of the ankle for aggressive tumors of the distal tibia in children.

作者信息

Stéphane Scharycki, Eric Mascard, Philippe Wicart, Félix Dubousset J, Raphael Seringe

机构信息

Saint Vincent de Paul Hospital, University of Paris René Descartes Paris V, Paris Cedex, France.

出版信息

J Pediatr Orthop. 2009 Oct-Nov;29(7):811-6. doi: 10.1097/BPO.0b013e3181b768ef.

Abstract

BACKGROUND

There is no consensus on the ideal treatment for malignant tumors of the distal tibia. Many favor amputation.

METHODS

Thirteen children, at an average age of 12 years (8 to 16 y) sustained conservative surgical treatment for a tumor of the distal tibia. All patients had "en bloc" resection of the tumor with ankle arthrodesis achieved by nail or plate accompanied by autograft.

RESULTS

The results were assessed retrospectively with an average follow-up of 8.8 years. Nine patients were in complete remission. Two patients had died. Two patients were lost to follow-up. Two patients had a local recurrence, which required amputation. There were 4 infections, which responded well to therapy. Four patients required additional bone grafting because of nonunion. Three patients required osteotomy for malalignment. Bone healing was achieved for the 9 patients seen at last follow-up. All were able to walk with an average functional score of 24.7/30 (23 to 26) on the Musculoskeletal Tumor Society score.

CONCLUSIONS

Several reconstructive techniques are available: mega prosthesis of distal tibia and ankle, reconstruction by vascularized fibula or by autograft. All series reported significant rates of infections, cutaneous necrosis, and nonunion.

DISCUSSION

Conservative treatment with ankle arthrodesis is a possible alternative to amputation for the management of malignant tumors of the distal tibia in selected patients. Survival results and functional outcome were good despite initial complications.

LEVEL OF EVIDENCE

This is a retrospectively therapeutic study graded level 2 as level of evidence.

摘要

背景

对于胫骨远端恶性肿瘤的理想治疗方法尚无共识。许多人倾向于截肢。

方法

13名平均年龄为12岁(8至16岁)的儿童接受了胫骨远端肿瘤的保守手术治疗。所有患者均对肿瘤进行了“整块”切除,通过髓内钉或钢板结合自体骨移植实现踝关节融合。

结果

对结果进行回顾性评估,平均随访8.8年。9名患者完全缓解。2名患者死亡。2名患者失访。2名患者局部复发,需要截肢。有4例感染,对治疗反应良好。4名患者因骨不连需要额外的骨移植。3名患者因畸形需要截骨。最后一次随访时见到的9名患者实现了骨愈合。所有患者均能行走,肌肉骨骼肿瘤学会评分的平均功能评分为24.7/30(23至26)。

结论

有几种重建技术可用:胫骨远端和踝关节的大型假体、带血管腓骨重建或自体骨移植。所有系列均报告了较高的感染、皮肤坏死和骨不连发生率。

讨论

对于选定患者的胫骨远端恶性肿瘤,踝关节融合的保守治疗是截肢的一种可能替代方法。尽管最初有并发症,但生存结果和功能结局良好。

证据水平

这是一项回顾性治疗研究,证据水平分级为2级。

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