[腺病毒载体甲型H5N1流感病毒疫苗免疫原性研究]
[Study on the immunogenicity of adeno-vector vaccine against H5N1 influenza A virus].
作者信息
Zhang Xiao-guang, Li Kui-biao, Ma Jing, Wang Nai-fu, Zhang Xiao-mei, Sang Yun-hu, Dong Jie, Xu Hong, Zeng Yi
机构信息
Peking Union Medical College, Beijing 100730, China.
出版信息
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009 Apr;23(2):97-9.
OBJECTIVE
To construct adenovirus vector vaccine against H5N1 influenza virus and study on the immunogenicity.
METHODS
In this study, we amplified hemagglutinin (HA) gene sequence of H5N1 influenza virus (A/Anhui/1/2005), then constructed an adenovirus vector vaccine (Adv-HA), followed by tests in BALB/c mice for the immunogenicity with the vaccine and immunization strategies.
RESULTS
The recombinate Adv-HA vaccine could effectively induce both humoral and cellular immunity against human H5N1 influenza virus.
CONCLUSION
The Adv-HA vaccination against H5N1 influenza is a potential strategy and worthy of further investigation.
目的
构建针对H5N1流感病毒的腺病毒载体疫苗并研究其免疫原性。
方法
本研究中，我们扩增了H5N1流感病毒（A/安徽/1/2005）的血凝素（HA）基因序列，随后构建了腺病毒载体疫苗（Adv-HA），接着在BALB/c小鼠中对该疫苗及其免疫策略的免疫原性进行测试。
结果
重组Adv-HA疫苗能有效诱导针对人H5N1流感病毒的体液免疫和细胞免疫。
结论
Adv-HA疫苗接种预防H5N1流感是一种有潜力的策略，值得进一步研究。
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