婴儿重症联合免疫缺陷患者的疫苗获得性轮状病毒。
Vaccine-acquired rotavirus in infants with severe combined immunodeficiency.
机构信息
Department of Pediatrics, Section of Allergy and Immunology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA.
出版信息
N Engl J Med. 2010 Jan 28;362(4):314-9. doi: 10.1056/NEJMoa0904485.
Abstract
Live pentavalent human-bovine reassortant rotavirus vaccine is recommended in the United States for routine immunization of infants. We describe three infants, two with failure to thrive, who had dehydration and diarrhea within 1 month after their first or second rotavirus immunization and subsequently received a diagnosis of severe combined immunodeficiency. Rotavirus was detected, by means of reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay, in stool specimens obtained from all three infants, and gene-sequence analysis revealed the presence of vaccine rotavirus. These infections raise concerns regarding the safety of rotavirus vaccine in severely immunocompromised patients.
摘要
在美国，五价口服轮状病毒活疫苗被推荐用于婴儿的常规免疫接种。我们描述了 3 名婴儿，其中 2 名有生长不良，在他们第一次或第二次轮状病毒免疫接种后 1 个月内出现脱水和腹泻，随后被诊断为严重联合免疫缺陷。通过逆转录-聚合酶链反应（RT-PCR）检测，从所有 3 名婴儿的粪便标本中均检测到轮状病毒，基因序列分析显示存在疫苗轮状病毒。这些感染引发了对严重免疫功能低下患者使用轮状病毒疫苗的安全性的关注。
相似文献
1
Vaccine-acquired rotavirus in infants with severe combined immunodeficiency.婴儿重症联合免疫缺陷患者的疫苗获得性轮状病毒。
N Engl J Med. 2010 Jan 28;362(4):314-9. doi: 10.1056/NEJMoa0904485.
2
Rotavirus shedding following administration of RV3-BB human neonatal rotavirus vaccine.接种RV3-BB人新生儿轮状病毒疫苗后的轮状病毒排毒情况。
Hum Vaccin Immunother. 2017 Aug 3;13(8):1908-1915. doi: 10.1080/21645515.2017.1323591. Epub 2017 May 8.
3
Rotavirus shedding in premature infants following first immunization.轮状病毒在早产儿首次免疫接种后的脱落。
Vaccine. 2011 Oct 19;29(45):8141-6. doi: 10.1016/j.vaccine.2011.08.028. Epub 2011 Aug 19.
4
Persistent systemic rotavirus vaccine infection in a child with X-linked severe combined immunodeficiency.持续性系统性轮状病毒感染患儿伴 X 连锁严重联合免疫缺陷。
J Med Virol. 2019 Jun;91(6):1008-1013. doi: 10.1002/jmv.25410. Epub 2019 Feb 6.
5
Multivalent Rotavirus Vaccine and Wild-type Rotavirus Strain Shedding in Australian Infants: A Birth Cohort Study.多价轮状病毒疫苗与澳大利亚婴儿野生型轮状病毒株脱落：一项出生队列研究。
Clin Infect Dis. 2018 Apr 17;66(9):1411-1418. doi: 10.1093/cid/cix1022.
6
Detection of mutations in antigenic regions of rotavirus viral proteins 4 and 7 in a child with chronic shedding of rotavirus vaccine-type strain.
Pediatr Infect Dis J. 2011 Jul;30(7):630. doi: 10.1097/INF.0b013e31821c38f2.
7
United States rotavirus strain surveillance from 2005 to 2008: genotype prevalence before and after vaccine introduction.2005 年至 2008 年美国轮状病毒株监测：疫苗引入前后的基因型流行率。
Pediatr Infect Dis J. 2011 Jan;30(1 Suppl):S42-7. doi: 10.1097/INF.0b013e3181fefd78.
8
Rotavirus vaccine--a powerful tool to combat deaths from diarrhea.轮状病毒疫苗——对抗腹泻致死的有力工具。
N Engl J Med. 2010 Jan 28;362(4):358-60. doi: 10.1056/NEJMe0912141.
9
Differentiation of RotaTeq vaccine strains from wild-type strains using NSP3 gene in reverse transcription polymerase chain reaction assay.在逆转录聚合酶链反应分析中使用NSP3基因区分罗特威疫苗株与野生型株。
J Virol Methods. 2016 Nov;237:72-78. doi: 10.1016/j.jviromet.2016.08.022. Epub 2016 Aug 30.
10
Monitoring Shedding of Five Genotypes of RotaTeq Vaccine Viruses by Genotype-Specific Real-Time Reverse Transcription-PCR Assays.应用基因型特异性实时 RT-PCR 检测方法监测五型 Rotateq 疫苗病毒的脱落情况。
J Clin Microbiol. 2018 May 25;56(6). doi: 10.1128/JCM.00035-18. Print 2018 Jun.
引用本文的文献
1
Rotavirus Infections: Pathophysiology, Symptoms, and Vaccination.轮状病毒感染：病理生理学、症状及疫苗接种
Pathogens. 2025 May 14;14(5):480. doi: 10.3390/pathogens14050480.
2
Recommendations on vaccination in children and adolescents with inborn errors of immunity according to the expanded Colombian immunization program.根据哥伦比亚扩大免疫规划对患有先天性免疫缺陷的儿童和青少年进行疫苗接种的建议。
Biomedica. 2024 Dec 23;44(Sp. 2):220-235. doi: 10.7705/biomedica.7424.
3
Protective role of antibodies in enteric virus infections: Lessons from primary and secondary immune deficiencies.抗体在肠道病毒感染中的保护作用：来自原发性和继发性免疫缺陷的经验教训。
Immunol Rev. 2024 Nov;328(1):243-264. doi: 10.1111/imr.13402. Epub 2024 Sep 28.
4
Terminalia Chebula Extract Replacing Zinc Oxide Enhances Antioxidant and Anti-Inflammatory Capabilities, Improves Growth Performance, and Promotes Intestinal Health in Weaned Piglets.诃子提取物替代氧化锌可增强断奶仔猪的抗氧化和抗炎能力，改善生长性能并促进肠道健康。
Antioxidants (Basel). 2024 Sep 5;13(9):1087. doi: 10.3390/antiox13091087.
5
Design of multi-epitope vaccine against porcine rotavirus using computational biology and molecular dynamics simulation approaches.基于计算生物学和分子动力学模拟方法设计抗猪轮状病毒的多表位疫苗。
Virol J. 2024 Jul 22;21(1):160. doi: 10.1186/s12985-024-02440-9.
6
Multiplex Real-Time PCR-Based Newborn Screening for Severe Primary Immunodeficiency and Spinal Muscular Atrophy in Osaka, Japan: Our Results after 3 Years.日本大阪地区基于多重实时 PCR 的新生儿严重原发性免疫缺陷病和脊髓性肌萎缩症的筛查：3 年后的结果。
Genes (Basel). 2024 Feb 28;15(3):314. doi: 10.3390/genes15030314.
7
Severe Combined Immunodeficiency-Classification, Microbiology Association and Treatment.重症联合免疫缺陷——分类、微生物学关联及治疗
Microorganisms. 2023 Jun 15;11(6):1589. doi: 10.3390/microorganisms11061589.
8
Preventive effect of (Gaertn.) Roxb. extract on mice infected with .石榴皮提取物对感染 的小鼠的预防作用。
Front Cell Infect Microbiol. 2023 Jan 9;12:1054205. doi: 10.3389/fcimb.2022.1054205. eCollection 2022.
9
Safety of Live Immunization in DiGeorge Syndrome: A Retrospective Single-Center Study in Korea, 2005-2021.2005 - 2021年韩国迪乔治综合征患者活疫苗免疫接种安全性：一项回顾性单中心研究
Vaccines (Basel). 2022 Dec 16;10(12):2165. doi: 10.3390/vaccines10122165.
10
Case Report: Mutations in causing severe combined immunodeficiency complicated by disseminated Bacille Calmette-Guérin disease and pneumonia.病例报告：导致严重联合免疫缺陷的 突变，并伴有播散性卡介苗病和 肺炎。
Front Immunol. 2022 Nov 17;13:1055607. doi: 10.3389/fimmu.2022.1055607. eCollection 2022.
本文引用的文献
1
2
Rotavirus vaccines: viral shedding and risk of transmission.轮状病毒疫苗：病毒排出与传播风险
Lancet Infect Dis. 2008 Oct;8(10):642-9. doi: 10.1016/S1473-3099(08)70231-7.
3
Successful treatment of disseminated BCG infection in a SCID patient with granulocyte colony stimulating factor.粒细胞集落刺激因子成功治疗一名重症联合免疫缺陷病患者的播散性卡介苗感染。
Asian Pac J Allergy Immunol. 2008 Mar;26(1):71-5.
4
Delayed onset and diminished magnitude of rotavirus activity--United States, November 2007-May 2008.轮状病毒活动的延迟发作和强度减弱——美国，2007年11月至2008年5月
MMWR Morb Mortal Wkly Rep. 2008 Jun 27;57(25):697-700.
5
Severe varicella caused by varicella-vaccine strain in a child with significant T-cell dysfunction.一名患有严重T细胞功能障碍的儿童因水痘疫苗株引起严重水痘。
Pediatrics. 2007 Nov;120(5):e1345-9. doi: 10.1542/peds.2004-1681.
6
Population-based newborn screening for severe combined immunodeficiency: steps toward implementation.基于人群的重症联合免疫缺陷新生儿筛查：实施步骤
J Allergy Clin Immunol. 2007 Oct;120(4):760-8. doi: 10.1016/j.jaci.2007.08.043.
7
Rotavirus infections in paediatric oncology patients: a matched-pairs analysis.儿科肿瘤患者的轮状病毒感染：配对分析
Scand J Gastroenterol. 2007 Jan;42(1):81-7. doi: 10.1080/00365520600842179.
8
Viremia and clinical manifestations in children with rotavirus infection.
J Infect Dis. 2006 May 1;193(9):1333. doi: 10.1086/501374.
9
Rotavirus and severe childhood diarrhea.轮状病毒与儿童严重腹泻
Emerg Infect Dis. 2006 Feb;12(2):304-6. doi: 10.3201/eid1202.050006.
10
Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine.一种五价人-牛（WC3）重组轮状病毒疫苗的安全性和有效性。
N Engl J Med. 2006 Jan 5;354(1):23-33. doi: 10.1056/NEJMoa052664.
Zotero 插件