Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA.
Clin Pharmacol Ther. 2010 Feb;87(2):160-2. doi: 10.1038/clpt.2009.284.
Pregnant women are at particularly high risk for morbidity and mortality from malaria, and pregnancy can markedly affect drug pharmacokinetics, yet the pharmacokinetics of antimalarial drugs in pregnancy has been little studied. An important malaria-control measure in Africa is intermittent preventive therapy (IPT) with sulfadoxine-pyrimethamine (SP) during pregnancy. We discuss IPT with SP in light of several concerns and highlight recent findings from a pharmacokinetic study of SP in this population.
孕妇因疟疾而发病和死亡的风险特别高，且妊娠可明显影响药物的药代动力学，但妊娠期间抗疟药物的药代动力学研究甚少。在非洲，一个重要的疟疾控制措施是在妊娠期间间歇性预防治疗（IPT）用磺胺多辛-乙胺嘧啶（SP）。我们根据一些关注问题讨论了 SP 的 IPT，并强调了最近在该人群中进行的 SP 药代动力学研究的发现。
