Department of Dermatology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Acta Derm Venereol. 2010;90(1):68-72. doi: 10.2340/00015555-0786.
The leukaemic form of cutaneous T-cell lymphoma, as represented by Sézary syndrome, exhibits erythroderma. We describe here an indolent leukaemic patient with cutaneous T-cell lymphoma, who initially had a nodulo-tumourous eruption with a crop of solid papules, but finally presented with papuloerythroderma. Histologically, the skin lesions showed non-epidermotropic dermal infiltration of atypical lymphocytes with lymphoid follicles and a granulomatous change. The circulating malignant CD4(+) CCR4(+) T cells lacked the expression of T-cell receptor and did not respond to concanavalin A. The unresponsiveness of T cells to the T-cell mitogen may be associated with the non-epidermotropic behaviour of the tumour cells and the initially non-erythrodermic eruption.
皮肤 T 细胞淋巴瘤的白血病形式，如蕈样肉芽肿，表现为红皮病。我们在这里描述了一位患有皮肤 T 细胞淋巴瘤的惰性白血病患者，他最初表现为结节性肿瘤性皮疹，伴有一批实性丘疹，但最终表现为斑丘疹性红皮病。组织学上，皮肤病变显示非表皮浸润的异型淋巴细胞，伴有淋巴滤泡和肉芽肿改变。循环恶性 CD4(+) CCR4(+) T 细胞缺乏 T 细胞受体的表达，对刀豆蛋白 A 无反应。T 细胞对 T 细胞有丝分裂原的无反应性可能与肿瘤细胞的非表皮浸润行为和最初的非红皮病性皮疹有关。
