[炎性纤维瘤性息肉：从瓦内克的“黏膜下肉芽肿”到黏膜下间叶性肿瘤的概念]
[Inflammatory fibroid polyp: from Vanek's "submucosal granuloma" to the concept of submucosal mesenchymal neoplasia].
作者信息
Schildhaus H-U, Merkelbach-Bruse S, Binot E, Büttner R, Wardelmann E
机构信息
Institut für Pathologie, Universitätsklinikum Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Deutschland.
出版信息
Pathologe. 2010 Mar;31(2):109-14. doi: 10.1007/s00292-009-1254-9.
Inflammatory fibroid polyps (IFP) were described by Vanek 60 years ago as "submucosal granuloma with eosinophilic infiltration". IFP represent polypous proliferations of spindle cells in the submucosa and mucosa of the stomach, small bowel and colon with inflammatory infiltration. The lesions have been regarded as inflammatory and reactive. Recent data show that the spindle cells express PDGFRA, and the majority of IFP harbour activating PDGFRA mutations. Therefore, IFP represent true benign mesenchymal tumors of the gastrointestinal tract.
60年前，瓦内克将炎性纤维性息肉（IFP）描述为“伴有嗜酸性粒细胞浸润的黏膜下肉芽肿”。IFP表现为胃、小肠和结肠黏膜下层和黏膜中梭形细胞的息肉样增生，并伴有炎症浸润。这些病变一直被视为炎症性和反应性病变。最近的数据显示，梭形细胞表达血小板衍生生长因子受体A（PDGFRA），并且大多数IFP存在激活的PDGFRA突变。因此，IFP是胃肠道真正的良性间叶性肿瘤。
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