Nikolov N, Liutskanov D
Vet Med Nauki. 1977;14(5):61-7.
Morphologic studies were carried out on birds aged 17 to 90 days, affected with Gumboro disease and occasionally died from the same disease (infectious bursitis). Established were hemorrhages in the leg and breast musculature, substantial enlargement of the bursa of Fabricius, and lesions in the kidneys. In some cases hemorrhages were also found on the serous membrane of the parenchymal organs. The histologic investigation of the involved parenchymal organs revealed necrobiotic changes (karyopycnosis, karyorrhexis) in the cellular elements, which were evaluated as a possible diagnostic symptom. Discussed is the problem of the dynamics of the morphologic changes observed in the bursa of Fabricius in view of their differential-diagnostic value.