Centro Clinico per le Neuronanotecnologie e la Neurostimolazione, Fondazione IRCCS Ospedale Maggiore, Policlinico, Mangiagalli e Regina Elena, Università di Milano, Milano, Italy.
Mov Disord. 2010 Feb 15;25(3):300-8. doi: 10.1002/mds.22982.
Deep brain stimulation (DBS) of the ventralis oralis (VO) complex of the thalamus improves tics in patients with Tourette syndrome (TS). To neurophysiologically describe the VO complex we recorded, in seven patients with TS undergoing DBS electrode implantation, single-unit activity during surgery and local field potentials (LFPs) a few days after surgery. Single unit recordings showed that the VO complex is characterized by a localized pattern of bursting neuronal activity. LFP spectra demonstrated that VO of TS patients has a prominent oscillatory activity at low frequencies (2-7 Hz) and in the alpha-band (8-13 Hz), and a virtually absent beta activity. In each patient, the main LFP frequency significantly correlated with single-unit interburst frequency. In conclusion, we observed an oscillatory bursting activity in the VO as target region in patients with severe TS undergoing DBS surgery.
丘脑腹侧被盖区（VO）深部脑刺激（DBS）可改善抽动秽语综合征（TS）患者的抽动。为了从神经生理学角度描述 VO 复合体，我们对 7 名接受 DBS 电极植入术的 TS 患者进行了手术期间的单单位活动和术后数天的局部场电位（LFP）记录。单单位记录显示，VO 复合体的特征是局部爆发性神经元活动。LFP 谱表明，TS 患者的 VO 具有低频（2-7 Hz）和 alpha 波段（8-13 Hz）的突出振荡活动，以及几乎不存在的 beta 活动。在每个患者中，主要的 LFP 频率与单单位爆发间频率显著相关。总之，我们在接受 DBS 手术的严重 TS 患者的 VO 区观察到了振荡爆发活动。
