Carsote Mara, Chirita Corina, Dumitrascu Anda, Hortopan D, Fica Simona, Poiana Catalina
Department of Endocrinology, "Carol Davila" University of Medicine and Pharmacy, 34-36 Bd. Aviatorilor, 011863 Bucharest, Romania.
J Med Life. 2009 Jan-Mar;2(1):92-7.
Clinical nonfunctional pituitary microadenomas, also known as incidentalomas are accidental observations made due to the application of high resolution imaging techniques as computed tomography or magnetic resonance. There are no standards regarding the follow-up of these tumors and taking into account their increased frequency among general population (during the last years they were based on the high performances of the imaging methods), we decided to study their dimensions and their evolution over time. We have also analysed their behavior with respect to their endocrine phenotype and the minimum period of time needed for the repetition of the imagistic procedure.
To observe the natural evolution of tumors' dimensions in a group of patients, diagnosed with nonfunctional pituitary microadenomas based upon hormonal measurements and computed tomography scan.
There is a retrospective observational study on 149 patients hospitalized in our Clinic between 1994 and 2006. Initially, all the pituitary hormones and the computed tomography were performed. Only nonfunctional microadenomas were included (the maximum diameter 11 mm). 69 patients were examined for a long period of time--29.75 +/- 24.79 months by CT scan and secretory profile, repeated at different periods of time.
At the end of 29.75 months, the aspect of microadenoma was still present, without any statistically significant changes of the diameter. One of the cases became macroadenoma and another proved to be a microprolactinoma. Only 5 cases of all 149 presented a double lesion. No case of pituitary apoplexy was registered. These observations lead to the conclusion that it is not necessary to repeat the computed tomography scan sooner than 2 years once the diagnosis ofincidentaloma was established.
临床无功能垂体微腺瘤，也称为偶发瘤，是由于应用计算机断层扫描或磁共振等高分辨率成像技术而偶然发现的。对于这些肿瘤的随访尚无标准，考虑到它们在普通人群中的发病率增加（在过去几年中，这是基于成像方法的高性能），我们决定研究它们的大小以及随时间的演变。我们还分析了它们在内分泌表型方面的行为以及重复成像检查所需的最短时间。
观察一组经激素测量和计算机断层扫描诊断为无功能垂体微腺瘤的患者中肿瘤大小的自然演变。
对1994年至2006年期间在我们诊所住院的149例患者进行回顾性观察研究。最初，进行了所有垂体激素检查和计算机断层扫描。仅纳入无功能微腺瘤（最大直径11毫米）。69例患者接受了长时间检查——通过CT扫描和分泌情况进行检查，在不同时间段重复进行，时间为29.75±24.79个月。
在29.75个月结束时，微腺瘤的情况仍然存在，直径没有任何统计学上的显著变化。其中1例变为大腺瘤，另1例被证明是微泌乳素瘤。149例中只有5例出现双病变。未记录到垂体卒中病例。这些观察结果得出结论，一旦确诊偶发瘤，在2年内不必过早重复计算机断层扫描。
