Instituto Superior Técnico, Av. Rovisco Pais, 1049-001 Lisbon, Portugal.
Expert Rev Vaccines. 2010 Feb;9(2):175-91. doi: 10.1586/erv.09.158.
Parasitic diseases are one of the most devastating causes of morbidity and mortality worldwide. Although immunization against these infections would be an ideal solution, the development of effective vaccines has been hampered by specific challenges posed by parasitic pathogens. Plasmid-based DNA vaccines may prove to be promising immunization tools in this area because vectors can be designed to integrate several antigens from different stages of the parasite life cycle or different subspecies; vaccines, formulations and immunization protocols can be tuned to match the immune response that offers protective immunity; and DNA vaccination is an affordable platform for developing countries. Partial and full protective immunity have been reported following DNA vaccination against the most significant parasitic diseases in the world.
寄生虫病是全球发病率和死亡率的最主要原因之一。尽管针对这些感染的免疫接种是一种理想的解决方案，但寄生虫病原体带来的特殊挑战阻碍了有效疫苗的研发。基于质粒的 DNA 疫苗可能成为该领域有前景的免疫接种工具，因为载体可以设计成整合寄生虫生命周期不同阶段或不同亚种的几种抗原；疫苗、配方和免疫接种方案可以调整以匹配提供保护免疫力的免疫反应；而且 DNA 疫苗接种是发展中国家负担得起的平台。针对世界上最重要的寄生虫病进行 DNA 疫苗接种后，已报告部分和完全保护免疫力。
