Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB21GA, UK.
Parasitology. 2010 Dec;137(14):2029-39. doi: 10.1017/S0031182009992034. Epub 2010 Jan 29.
Trypanosoma brucei is exposed to the adaptive immune system and complement in the blood of its mammalian hosts. The aim of this review is to analyse the role and regulation of the proteins present on the external face of the plasma membrane in the long-term persistence of an infection and transmission. In particular, the following are addressed: (1) antigenic variation of the variant surface glycoprotein (VSG), (2) the formation of an effective VSG barrier shielding invariant surface proteins, and (3) the rapid uptake of VSG antibody complexes combined with degradation of the immunoglobulin and recycling of the VSG.
布氏锥虫在其哺乳动物宿主的血液中暴露于适应性免疫系统和补体。本综述的目的是分析质膜外表面存在的蛋白质在感染和传播的长期持续中的作用和调节。具体来说，涉及以下几个方面：（1）变异表面糖蛋白（VSG）的抗原变异，（2）形成有效的 VSG 屏障，屏蔽不变表面蛋白，以及（3）快速摄取 VSG 抗体复合物，同时降解免疫球蛋白并回收 VSG。
