Corbin V, Vidal M, Beytout J, Laurichesse H, D'Incan M, Souteyrand P, Lesens O
Service des maladies infectieuses et tropicales, CHU de Clermont-Ferrand, 63000 Clermont-Ferrand, France.
Ann Dermatol Venereol. 2010 Jan;137(1):5-11. doi: 10.1016/j.annder.2009.12.002. Epub 2009 Dec 30.
The LRINEC score was developed in a retrospective study in order to distinguish necrotizing fasciitis from severe soft tissue infections using laboratory data.
To evaluate the prognostic value of the LRINEC score in infectious cellulitis.
A prospective study was performed at the departments of infectious diseases and dermatology of the Clermont-Ferrand University Hospital. The three evaluation criteria were: time from initiation of antibiotics to regression of erythema, duration of fever and occurrence of complications (abscess, surgery, septic shock, necrotizing fasciitis, death, transfer to intensive care). Potential predictive variables were: LRINEC score>6 at admission, comorbidities, local appearance, clinical presentation and soft tissue ultrasound results.
Fifty patients were included. The rate of complications was higher for patients with a LRINEC score>6 (54%) than for patients with a score<6 (12%, P=0.008). However, a LRINEC score>6 on admission was not significantly associated with increased duration of erythema or of fever. Prior lymphoedema was associated with a better prognosis.
The LRINEC score may be a useful tool for the detection of complicated forms of soft tissue infections. Patients with a LRINEC score>6 on admission should be carefully evaluated (hospitalization, surgical assessment, close monitoring).
LRINEC评分是在一项回顾性研究中制定的，目的是利用实验室数据将坏死性筋膜炎与严重软组织感染区分开来。
评估LRINEC评分在感染性蜂窝织炎中的预后价值。
在克莱蒙费朗大学医院的传染病科和皮肤科进行了一项前瞻性研究。三项评估标准为：从开始使用抗生素到红斑消退的时间、发热持续时间以及并发症（脓肿、手术、感染性休克、坏死性筋膜炎、死亡、转入重症监护病房）的发生情况。潜在的预测变量为：入院时LRINEC评分>6、合并症、局部表现、临床表现及软组织超声结果。
纳入50例患者。LRINEC评分>6的患者并发症发生率（54%）高于评分<6的患者（12%，P=0.008）。然而，入院时LRINEC评分>6与红斑或发热持续时间延长无显著相关性。既往淋巴水肿与较好的预后相关。
LRINEC评分可能是检测复杂形式软组织感染的有用工具。入院时LRINEC评分>6的患者应进行仔细评估（住院、手术评估、密切监测）。
