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[在莱里达健康地区实施商定的治疗流程之前,对短暂性脑缺血发作患者的预后影响进行研究]

[Study of the prognostic implications in patients with a transient ischaemic attack before the implementation of an agreed process of treatment in the health region of Lleida].

作者信息

Purroy F, Solé A, Oró M, Quilez-Martínez A, Llobet C, Sanahuja-Montesinos J, Brieva L, Cabré-Ollé X, Setó E, Piñol-Ripoll G

机构信息

Hospital Universitari Arnau de Vilanova, 25006 Lleida, Espana.

出版信息

Rev Neurol. 2010;50(2):77-83.

Abstract

AIM

The transient ischemic attack (TIA) is a medical emergency because of their high risk of early recurrence. We study the evolution and management of patients with a TIA in our hospital before establishing a process management and treatment of this condition.

PATIENTS AND METHODS

We included 180 consecutive patients with suspected TIA attended in the emergency department of our hospital between January 2006 and March 2007. We collected clinical variables (risk factors, age, clinical symptoms, duration, ABCD2). Cases were reviewed by two neurologists to establish the correlation with the diagnosis. We established the risk of cerebral infarction after one year follow-up.

RESULTS

31% of patients were discharged home. There were differences between the two groups regarding age (82.9 Y 7.5 vs 70.53 Y 10.7 years); ABCD2 scale score (1.5 Y 5.32 vs 4.44 Y 1.37); and atrial fibrillation (27.5% vs 8.6%). There was much greater delay and lack of complementary explorations. During follow-up, 23% of patients not hospitalized had recurrent stroke versus 6.7% of hospitalized patients. Despite the fact that only age more than 80 years was identified as predictor of stroke recurrence (hazard ratio = 8,72; 95% CI = 2.4-31.74; p = 0.001) in regression multivariate model, the Kaplan-Meier model showed a higher risk of stroke recurrence among not admitted patients (p = 0.012).

CONCLUSION

In our area, the management of TIA patients in the emergency room had high impact on the evolution of these patients. A process management should be performed in order to achieve improvement in clinical praxis.

摘要

目的

短暂性脑缺血发作(TIA)因其早期复发风险高而属于医疗急症。在建立针对该病症的流程管理和治疗方法之前,我们对我院TIA患者的病情发展及治疗情况进行了研究。

患者与方法

我们纳入了2006年1月至2007年3月期间在我院急诊科就诊的180例连续的疑似TIA患者。我们收集了临床变量(危险因素、年龄、临床症状、发作持续时间、ABCD2评分)。由两位神经科医生对病例进行复查以确定与诊断的相关性。在随访一年后,我们确定了脑梗死的风险。

结果

31%的患者出院回家。两组在年龄(82.9岁±7.5岁与70.53岁±10.7岁)、ABCD2量表评分(1.5±5.32与4.44±1.37)以及心房颤动(27.5%与8.6%)方面存在差异。在检查延迟和缺乏辅助检查方面差异更大。在随访期间,未住院患者中有23%发生了复发性卒中,而住院患者中这一比例为6.7%。尽管在多变量回归模型中仅确定年龄超过80岁是卒中复发的预测因素(风险比=8.72;95%置信区间=2.4 - 31.74;p = 0.001),但Kaplan - Meier模型显示未入院患者卒中复发风险更高(p = 0.012)。

结论

在我们地区,急诊科对TIA患者的管理对这些患者的病情发展有很大影响。应进行流程管理以改善临床实践。

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