治疗妊娠期局限性牙周病并不会降低早产的发生风险：来自牙周感染与早产研究（PIPS）的结果。

Treatment of localized periodontal disease in pregnancy does not reduce the occurrence of preterm birth: results from the Periodontal Infections and Prematurity Study (PIPS).

机构信息

Department of Obstetrics and Gynecology, Washington University in St. Louis, School of Medicine, Campus Box 8064, 4911 Barnes-Jewish Hospital Plaza, St. Louis, MO 63110-1094, USA.

出版信息

Am J Obstet Gynecol. 2010 Feb;202(2):147.e1-8. doi: 10.1016/j.ajog.2009.10.892.

DOI:10.1016/j.ajog.2009.10.892

PMID:20113691

Abstract

OBJECTIVE

The purpose of this study was to test whether treating periodontal disease (PD) in pregnancy will reduce the incidence of spontaneous preterm delivery (SPTD) at < or = 35 weeks of gestation.

STUDY DESIGN

A multicenter, randomized clinical trial was performed. Subjects with PD were randomized to scaling and root planing (active) or tooth polishing (control). The primary outcome was the occurrence of SPTD at <35 weeks of gestation.

RESULTS

We screened 3563 subjects for PD; the prevalence of PD was 50%. Seven hundred fifty-seven subjects were assigned randomly; 378 subjects were assigned to the active group, and 379 subjects were assigned to the placebo group. Active treatment did not reduce the risk of SPTD at <35 weeks of gestation (relative risk, 1.19; 95% confidence interval [CI], 0.62-2.28) or composite neonatal morbidity (relative risk, 1.30; 95% CI, 0.83-2.04). There was a suggestion of an increase in the risk of indicated SPTD at <35 weeks of gestation in those subjects who received active treatment (relative risk, 3.01; 95% CI, 0.95-4.24).

CONCLUSION

Treating periodontal disease does not reduce the incidence of SPTD.

摘要

目的

本研究旨在检验治疗孕期牙周病（PD）是否会降低妊娠 35 周及以下自发性早产（SPTD）的发生率。

研究设计

进行了一项多中心、随机临床试验。患有 PD 的受试者被随机分为刮治和根面平整（主动）或牙齿抛光（对照）组。主要结局是发生妊娠 35 周前的 SPTD。

结果

我们筛查了 3563 例 PD 患者；PD 的患病率为 50%。757 例患者被随机分配；378 例患者被分配到主动组，379 例患者被分配到安慰剂组。主动治疗并未降低妊娠 35 周前 SPTD 的风险（相对风险，1.19；95%置信区间[CI]，0.62-2.28）或复合新生儿发病率（相对风险，1.30；95%CI，0.83-2.04）。在接受主动治疗的受试者中，妊娠 35 周前有指征的 SPTD 风险呈增加趋势（相对风险，3.01；95%CI，0.95-4.24）。